The main objective of the current project is to assess postprandial metabolic responses when graded amounts of whole-food dairy products are incorporated in a breakfast . Furthermore, we aim to explore the potential of jumping exercise to enhance…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Glucose- en botmetabolisme bij gezonde mensen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Post-prandial metabolic response as assessed by amino acids concentrations, and
the bone formation marker procollagen type I N propeptide
Secondary outcome
Post-prandial metabolic response as assessed by glucose metabolism (glucose,
insulin, GLP-1) and bone metabolism (calcium, PTH, CTX). Hunger and satiety
will be assessed by means of a VAS scale.
Background summary
Dietary protein has several important health effects on muscle and bone tissue
, and is associated with several health outcomes such as improved
cardiovascular risk. In general, people have a skewed distribution of protein
intake, with protein intakes at breakfast below recommendations for optimal
muscle health. Besides contributing to muscle and bone health, increasing
protein intake with breakfast can aid in weight management, as increased
protein intakes are associated with increased satiety following food intake.
Also, the co-ingestion of protein with carbohydrates is associated with a more
favorable glycemic response. Dairy protein may be a favorable protein source as
it contains other nutrients that can substantially improve the quality of
breakfast, such as vitamin B2 and B12, potassium, calcium and phosphorus. The
benefits of (high doses of) isolated milk-derived nutrients for muscle health,
postprandial glycemic control, satiety, and bone metabolism have been well
established. However, much of the evidence cannot be directly translated to
daily life, as people consume mixed diets rather than isolated nutrients.
Study objective
The main objective of the current project is to assess postprandial metabolic
responses when graded amounts of whole-food dairy products are incorporated in
a breakfast . Furthermore, we aim to explore the potential of jumping exercise
to enhance the benefits of dairy on bone metabolism.
Study design
Open-label randomized crossover trial.
Intervention
In a randomized order, all participants will consume a carbohydrate-rich
breakfast with graded amounts of dairy protein with or without postprandial
jumping exercise.
Participants will beexposed to the following conditions in a randomized order:
1. Common high-carbohydrate breakfast: bread, tea with sugar, half-fat margarin
and marmalade (LOW*)
2. Breakfast with milk: bread, milk, half-fat margarin and marmalade (MOD*)
3. Breakfast with milk and cheese: bread, milk, half-fat margarin, cheese
(HIGH*)
4. Breakfast with milk and cheese: bread, milk, half-fat margarin, cheese.
Followed by a ~5-min bout of jumping exercise to stimulate bone formation
(HIGH+JUMP*).
*LOW = low dairy intake (~10 g protein); SUB = moderate dairy intake (~16 g
protein); HIGH = high dairy intake (~26 g protein); HIGH+JUMP = high dairy
intake (~26 g protein) + ~5 min jumping exercise.
Study burden and risks
• Participants will visit our lab 7 times (1 x ~30 min, i.e. screening; 4 x
~5.5 h, i.e. test day; 2 x 10 min, i.e. test day).
• Overall, 10 blood samples (~8-12 mL/sample) per test day will be drawn via an
intravenous canula. After 2 test days participants will return to our lab 24h
post breakfast for a single blood sample by vena puncture. The discomfort
associated with inserting an intravenous canula is transient and is comparable
to having an injection by a needle, or donating blood.
• The ~5 min jumping exercise intervention consists of non-exhaustive rope
skipping-type exercise.
• The consumed breakfast will contain regular food products purchased in a
supermarket.
• BMD and body composition will be assessed once by DXA. The measurement is
painless, non-invasive and involves only low radiation exposure (<10 µSv).
Altogether, it can be concluded that the burden and risks associated with this
study are limited.
Heyendaalseweg 141
Nijmegen 6525 AJ
NL
Heyendaalseweg 141
Nijmegen 6525 AJ
NL
Listed location countries
Age
Inclusion criteria
• Age >=20 and <=40 years.
• BMI >=18.5 and <=27.5 kg/m2
• Willing to give blood samples
Exclusion criteria
• Blood donation during the study period
• Currently smoking
• Consumption of >21 alcoholic beverages per week
• Use of illicit drugs
• Regular use of protein supplements.
• A self-reported reported lactose intolerance, allergy or sensitivity to dairy
ingredients
• Reported slimming or medically prescribed diet
• Use of antibiotics in the past month
• Medical condition that can interfere with the study outcome (i.e.
cardiovascular disease, pulmonary disease, rheumatoid arthritis, orthopaedic
disorders, renal disease, liver disease, diabetes mellitus, inflammatory
disease, cognitive impairment, and thyroid or parathyroid disease)
• Use of medications known to interfere with selected outcome measures (i.e.
corticosteroids)
• (Chronic) injuries of the locomotor system that can interfere with the
intervention.
• Current participation in another biomedical research study.
• Trained individuals (i.e. performing sport activities for more than 6 hours
per week).
• Structural or competitively participating in exercise/ sports with a
substantial high-impact component, such as soccer, volleyball, running, and
lower body resistance training.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL80607.096.22 |