The purpose of this study is to evaluate whether consumption of canola and whey protein when compared to a placebo stimulates muscle growth after resistance exercise.
ID
Source
Brief title
Condition
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Postprandial muscle protein synthesis rates (0-5h)
Secondary outcome
Basal muscle protein synthesis rates
Plasma glucose, insulin, amino acids + corresponding peak values and (i)AUC
Plasma 13C6-phe enrichments
Muscle signalling pathways
Background summary
Muscle tissue consists of proteins. These proteins are built up of small
building blocks: amino acids. By consuming enough protein in our diet, we make
sure that the body is provided with enough amino acids to facilitate muscle
protein building. Providing the growing world population with sufficient
animal-derived protein is a challenge. Plant proteins can be produced on a more
sustainable commercial scale than conventional animal-derived proteins and
therefore, can contribute to feeding our future population. Canola protein is a
protein that is derived from rapeseed. The composition of canola seems to be
comparable to that of other high-quality animal-based protein sources. But
there is no data yet on the effect of canola protein ingestion on muscle
growth. Additionally, most research on the effect of protein intake and muscle
growth/recovery has been performed in males and we need more insight into the
effect in females.
Study objective
The purpose of this study is to evaluate whether consumption of canola and whey
protein when compared to a placebo stimulates muscle growth after resistance
exercise.
Study design
randomized, controlled, parallel-group, double-blind intervention trial
Intervention
20g Whey protein, 20g canola protein, or non-caloric placebo drink
Strength exercise
Study burden and risks
The burden and risks associated with this study are moderate. It is a short
study (1.5 days) with a few invasive, but low-risk measurements.
it is possible that for a few days there is a feeling of soreness after the
biopsies which is comparable to the soreness after bumping into a table. Also,
there is a possibility of some additional bleeding after the biopsies. For 3
biopsies this risk is present 3 times in total, but it is no major health risk.
Placing the cannulas during the test day can be uncomfortable and can result in
a small hematoma. However, this makes the 12 blood draws relatively easy. The
amount of blood that is drawn (130 mL) is way less than an average blood
donation and will recover within a month.
In total, participants visit the university twice, being fasted on both
occasions. On the test day participants will stay fasted for a longer time,
which can cause a feeling of hunger. Water drinking is allowed and unlimited.
Furthermore, the participants will fill out diaries 2 days prior to the test
day that will cost 30 minutes. During these days, they are also not allowed to
drink alcohol or do heavy physical activities.
The strength test and strength training will be performed under supervision,
but can be a bit exhausting and cause some muscle soreness when the participant
is not used to doing these exercises.
The dexa scan provides valuable data about the body composition, but has a
small radiation burden. This burden is negligible when compared to the yearly
background radiation.
The drinks will consist of 500 mL and will have to be consumed within 5 minutes.
There is no direct benefit for the participants, only their contribution to
scientific knowledge. The participants will get more insight into their body
composition and sports performance (maximal muscle strength)
Universiteitssingel 50
Maastricht 6229ER
NL
Universiteitssingel 50
Maastricht 6229ER
NL
Listed location countries
Age
Inclusion criteria
• Female sex
• Age between 18 and 35 y inclusive
• BMI between 18.5 and 30 kg/m2
• Having given informed consent
Exclusion criteria
• Intolerant to milk products
• Mustard allergy
• Participating in a structured (progressive) exercise program
• Smoking regularly
• Diagnosed GI tract disorders or diseases
• Diagnosed musculoskeletal disorders
• Diagnosed metabolic disorders (e.g. diabetes)
• Hypertension (blood pressure above 140/90 mmHg)
• Donated blood 3 months prior to test day
• Pregnant
• Using third generation oral contraceptives
• Use of any medications known to affect protein metabolism (i.e.
corticosteroids, non-steroidal anti-inflammatories).
• Chronic use of gastric acid suppressing medication
• Chronic use of anti-coagulants
• Recent (<1 year) participation in amino acid tracer
(L-[ring-13C6]-phenylalanine and L-[3,5-2H2]-tyrosine studies
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL81203.068.22 |