EDGI aims to enhance the understanding of the underlying biology and genetic architecture of the different eating disorders. Therefore GWA analyses (both within and cross disorder analyses) will be performed in the EDGI samples combined with the PGC…
ID
Source
Brief title
Condition
- Eating disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Online self-report questionnaires to assess: lifetime eating disorder
diagnosis, eating disorder psychopathology. DNA of participants will be
isolated from a saliva sample.
Secondary outcome
Online self-report questionnaires to asses: treatment and impact of eating
disorder, quality of life, obsessive compulsive disorder, mood and anxiety
symptoms, substance use, life events, excessive exercise and perfectionism
Background summary
Eating disorders (anorexia nervosa [AN], bulimia nervosa [BN] and binge eating
disorder [BED]) are severe psychiatric disorders. Little is known about the
aetiology of eating disorders, but there seems to be a substantial heritable
component. To advance genetic discovery of biologically, clinically, and
therapeutically meaningful insights large samples of cases with eating
disorders and controls are required to perform Genome Wide Association (GWA)
Studies. The Eating Disorders Genetics Initiative (EDGI) is an international
collaboration designed to recruit 4,500 individuals with AN, 5,950 individuals
with BN, 4,050 individuals with BED and 1,500 ancestrally matched controls. The
current EDGI-NL project will recruit Dutch cases with eating disorders and
controls to contribute to EDGI and the Eating Disorders workgroup of the
Psychiatric Genomics Consortium (PGC-ED).
Study objective
EDGI aims to enhance the understanding of the underlying biology and genetic
architecture of the different eating disorders. Therefore GWA analyses (both
within and cross disorder analyses) will be performed in the EDGI samples
combined with the PGC-ED samples (total 35,000 cases, 100,000 controls). The
EDGI-NL project will ascertain Dutch eating disorder cases and controls and
contribute to the EDGI project and goals by delivering DNA and questionnaire
data of at least 200 cases with AN, 200 cases with BN, 100 cases with BED and
150 controls.
Study design
Observational study, using a cross-sectional case-control design at least 200
cases with AN, 200 cases with BN, 100 cases with BED and 150 controls will be
ascertained. Participation in the study consists of three steps (1. Online
screening questionnaire; 2. Additional online questionnaires; 3. Collection
saliva sample at home and returned by mail) and will take approximately three
hours. The consent procedure exists of two parts. First the participant has to
give consent for the first part of the study (the screening questionnaire). If
the participant is eligible to take part in the rest of the study, the research
team will contact the participant by telephone for a check (information on the
study, are there any questions concerning the research, does the participant
understand what he/she will give consent for). Then they will receive a second
information letter by Email. At the end of this information a link to a secure
online consent form is given. After the participant completed the consent form,
the participant will continue with part two and three of the study.
Study burden and risks
Participation in the study consists of three steps (1. Online screening
questionnaire; 2. Additional online questionnaires; 3. Collection saliva
sample) and will take approximately three hours. The saliva sample can be
collected at home and returned by mail. Phenotypic information will be
ascertained online, questionnaires do not have to be completed at once, but can
be completed in parts.If participants are eligible to take part in the study,
based on the screening questionniare, and they complete the additional online
questionnaires and collect the spit sample, they will receive a ¤20 Bol.com
gift card.
Sandifortdreef 19
Leiden 2333 ZZ
NL
Sandifortdreef 19
Leiden 2333 ZZ
NL
Listed location countries
Age
Inclusion criteria
Patients:
-fulfil criteria for a lifetime history for AN, BN or BED according to the DSM-5
-between 18 and 65 years old
-be able to understand and complete the questionnaires of the EDGI-NL study
Controls:
-lifetime adult minimum BMI>18.5 kg/m2
-no history of an eating disorder or disordered eating behaviours
-between 18 and 65 years old
-be able to understand and complete the questionnaires of the EDGI-NL study
Exclusion criteria
none
Design
Recruitment
metc-ldd@lumc.nl
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL77279.058.21 |