To optimize (early) diagnosis and risk-stratification of (early) cardiomyopathy phenotypes and to create a better understanding of underlying pathophysiological processes.
ID
Source
Brief title
Condition
- Heart failures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
This is a prospective registry from which multiple research questions can be
answered. In general, two main approaches will be used: (A) a data-driven
(multi-)omics approach which aims to identify clusters of patients to predict
clinical outcome, to improve (early) diagnosis, and/or to identify clusters of
patients that share underlying pathophysiological processes; (B) a
hypothesis-driven approach in which clinical parameters are tested for their
(incremental) diagnostic and/or prognostic value.
Secondary outcome
.
Background summary
Heart failure (HF) represents a heterogeneous range of clinical overlapping
cardiomyopathy phenotypes, resulting from multifactorial environmental insults
in the presence or absence of a genetic predisposition. A better understanding
of (early) cardiomyopathy phenotypes, their underlying pathophysiological
processes, and their related disease burden is key to pave the way for novel
preventive and/or intervention studies.
Study objective
To optimize (early) diagnosis and risk-stratification of (early) cardiomyopathy
phenotypes and to create a better understanding of underlying
pathophysiological processes.
Study design
The Multicenter Cardiology Moniroting Platform (mCMP-registry) is an
investigator-initiated multicenter (Maastricht University Medical Center,
University Medical Center Groningen, University Medical Center Utrecht,
Zuyderland Medical Center) prospective observational registry including
multi-omics (diagnostic) measurements performed as part of routine clinical
care, bio-banking (optional), and yearly questionnaires (optional).
Study burden and risks
There is not any risk associated with the participation in this study.
P. Debyelaan 25
Maastricht 6229HX
NL
P. Debyelaan 25
Maastricht 6229HX
NL
Listed location countries
Age
Inclusion criteria
- Referred to a cardiology or genetic department for heart failure like
symptoms (as stated in the ESC 2016 Guidelines(3)) or for cardiac/cardiogenetic
screening;
- Age >=16 years.
Exclusion criteria
- Unwillingness to participate or unable to give written informed consent (e.g.
due to language barriers or severe intellectual disability).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| ClinicalTrials.gov | NCT04976348 |
| CCMO | NL76585.068.21 |