To understand walking-related factors that contribute to fatigue and the relationship with total physical activity and social participation in daily life among pwRA and pwOA.
ID
Source
Brief title
Condition
- Other condition
- Autoimmune disorders
Synonym
Health condition
osteoartrose
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Cost of walking
- Preferred walking speed
- Walking fatigability
Secondary outcome
- Biomechanical characteristics of walking
- Daily physical activity
- Social role participation
- Daily life fatigue
- Physical activity and health
- Instantaneous perceived fatigue
Background summary
Persons with Rheumatoid Arthritis (pwRA) and persons with osteoartrosis (pwOA)
experience increased fatigue in daily life of which a small part is explained
by direct effects of disease activity such as pain and inflammation. Walking,
as the core daily activity of humans, is altered in pwRA and pwOA compared to
healthy subjects. The observed lower walking speed in pwRA and pwOA is not
only related to lower quality of life but also with higher levels of fatigue.
Underlying mechanisms supporting this relationship are currently unknown. When
considering the biomechanical principles of gait in healthy subjects, the
preferred walking speed is also the walking speed with the lowest energetic
cost. When translating this to pwRA or pwOA, the lower preferred walking speed
is expected to increase the energetic demand during walking, referred to as the
Cost of walking (Cw). Thus, insight into overall fatigue among pwRA or pwOA
compared to healthy subjects, might be improved by understanding the
relationship between (a) Cw of the preferred walking speed and the
energetically most efficient walking speed on the one hand, and (b) walking
speed, Cw, biomechanical walking characteristics and fatigability during
walking. Secondary, the Cw and the presence of fatigability, will be related to
total daily activity and participation, to help us better understand fatigue in
RA and OA.
Study objective
To understand walking-related factors that contribute to fatigue and the
relationship with total physical activity and social participation in daily
life among pwRA and pwOA.
Study design
An exploratory observational case-control study
Study burden and risks
The participants might feel fatigued after performing the walking trials.
Universiteitssingel 50
Maastricht 6226ER
NL
Universiteitssingel 50
Maastricht 6226ER
NL
Listed location countries
Age
Inclusion criteria
- Diagnosed Rheumatoid Arthritis or hip Osteoarthrosis
- Not in remission (Disease Activity Score >2.6 OR erosions in the feet for
pwRA)
- Age range 18-70
- Walking without walking aid/ orthosis
- Understanding Dutch language
Exclusion criteria
- Arthroplasty of Hip/Knee/Ankle/Shoulder
- Severe arthrosis Hip/Knee/Ankle/Shoulder (as an indication for surgery)
- Recent fracture of lower limb affecting gait (<12 months)
- Contra indication for physical activity
- Comorbidities affecting gait (COPD, Parkinsons disease)
- Fixation lumbar and cervical spine (atlas-dens)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL72955.068.20 |