The aim is to develop a method that can be used to determine, already in the ambulance, whether a patient suffers a stroke and if so, what the cause of stroke is. In this project we want to develop nanotechnology that is capable of detecting…
ID
Source
Brief title
Condition
- Neurological disorders NEC
- Vascular disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The collected blood will be analysed on the presence of differentiating
markers, in this case EV concentrations, that can be related to different
causes of stroke.
It will be examined whether ischemic strokes can be differentiated from
hemorrhagic strokes and stroke mimics. Moreover, in the ischemic stroke group
it will be examined whether small vessel occlusions can be discriminated from
large-vessel occlusions.
Secondary outcome
Secondary, relations between the EV concentration(s) and other clinical and
radiological findings than the diagnosis will be explored.
Background summary
In the Western world, stroke is the most frequent cause of major diability and
the third cause of death. Half of the stroke survivors need life-long medical
support. The causes of stroke can be subdivided into hemorrhagic stroke
(ruptured artery) or an ischemic stroke (blocked artery). These different
subtypes of stroke need different acute treatment approaches. The 'Time is
brain' principle is thereby crucial, because 2 million brain cells die per
minute in an acute stroke. Currently, a CT-scan made in the nearest hospital
determines the exact cause of stroke, which is used to decide whether the
patient needs further transport to a comprehensive stroke center, thereby
losing precious time.
We hypothesize that there are blood markers that could be used to diagnose the
cause of stroke.
Study objective
The aim is to develop a method that can be used to determine, already in the
ambulance, whether a patient suffers a stroke and if so, what the cause of
stroke is. In this project we want to develop nanotechnology that is capable of
detecting nanotraces within the blood. If successful, this would contribute to
the improvent of current diagnostics.
The composition and concentration of extracellular vesicles (EVs) in blood will
be determined and it will be examined which EVs might differentiate between
ischemic and hemorrhagic stroke. Moreover, it will be examined whether
differences can be found between the EV concentration of small- and large
vessel occlusions. It is also of interest whether the concentrations of EVs is
related to the location of stroke.
Study design
This concerns a multicenter observational study.
Study burden and risks
The burden and risks associated with participation are considered low.
In this study, extra blood will be collected once (10 mL maximal),
simultaneously with the regular blood collection. The risks associated with a
venepuncture are considered negligible.
Despite the study population consists of (possibly) incapacitated patients (due
to brain damage caused by the stroke), the researchers consider the burden and
risks justified. This study cannot be done with patient groups different than
the one described.
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
- Age 18 years or older
- Presenting with symptoms suggestive of stroke
- Written informed consent (deferred)
Exclusion criteria
Untreated coagulation abnormalities
Specific stroke treatment has started before study blood has been collected
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL72929.018.20 |
| OMON | NL-OMON27763 |