To investigate neural response patterns to visually and orally presented palatable (high vs low caloric) and unpalatable (high vs low caloric) foods in AN patients and matched healthy controls (HC). This will be investigated through 1 study with 2…
ID
Source
Brief title
Condition
- Eating disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Study 1: The effect of these manipulated attentional focus on brain regions
related to inhibitory control and reward processing.
Study 2: The effect of informed and uninformed food caloric content on neural
expectancy response and initial neural taste response.
Secondary outcome
Study 2: The effect of palatability vs tension on neural activity while tasting
food.
Background summary
Anorexia Nervosa (AN) is one of the more difficult to treat psychiatric
disorders, characterised by a high mortality rate and highly anxiogenic view of
food in general. In a meta-review investigating mortality rates in mental
disorders, it was found that Anorexia Nervosa had one of the highest, exceeded
only by substance use disorders. It is therefore of great importance that we
understand the disease and improve treatment. However, the complexity of AN is
manifested in the pervasive sense of doubt still surrounding the aetiology of
the disease. In an effort to come ever closer to a more comprehensive
understanding of the origins of the disorder, these studies investigate the
neural mechanisms underpinning food-choice processing in persons with AN using
functional magnetic resonance imaging (fMRI). In the first study, we will
investigate neural response patterns to visually presented palatable (pleasant
to taste) and unpalatable (unpleasant to taste) high caloric and low caloric
food images in AN patients and matched healthy control participants (HC). We
assume that AN patients make decisions relating to food based on caloric
content rather than taste. We will give the participants a clear
food-evaluation task, to have much more control over the engaged mental
process, enabling stronger conclusions from the neural results. Specifically,
while in the scanner, participants will be asked to perform a food evaluation
task focusing on palatability, calorie content or a neutral aspect of the
presented food images. The second study aims to investigate the neural
responses to both the a) expectation and actual b) receipt of highly palatable
(fat and sweet) taste stimuli in AN-patients vs healthy controls. We
hypothesize that Anorexics will have the same initial taste perception as that
of healthy persons but that this will quickly be overtaken by inhibitory
responses in areas of the brain designated to cognitive control.This study will
focus on the reward and taste areas of the gustatory system as well as
inhibitory control processing areas such as the anterior cingulate cortex (ACC)
and the dorsolateral prefrontal cortex (dlPFC) as those areas are implicated in
cognitive control in the anorectic brain.
Study objective
To investigate neural response patterns to visually and orally presented
palatable (high vs low caloric) and unpalatable (high vs low caloric) foods in
AN patients and matched healthy controls (HC). This will be investigated
through 1 study with 2 parts.
Study design
Part 1 - This experiment will be a block design, experimental fMRI study. The
participants will view individually tailored highly palatable and highly
unpalatable food images in the fMRI scanner while attentional focus is
manipulated in 3 ways. Participants will be required to perform a one-back task
while viewing the images.
Part 2 - This experiment will be a block design experimental fMRI study. The
participants will taste versions of a high caloric and low caloric milk drink
while in the scanner. The study design also consists of subjective ratings of
tension and palatability of the milk drink at the end of each block.
Study burden and risks
The proposed study carries minimal risks and discomfort, but is time consuming
for the participants. However, the information they deliver significantly
improves insight into the relationship between cognitions and biological
responses related to food desires (or lack thereof) as well as actual eating
behaviour in AN. As an incentive and compensation for participation in the
study, the participants will receive ¤20 in VVV vouchers after completing the
study. We will also include cost of travel and travel arrangements for those AN
patients coming from contributing centres.
Maastricht 40
Maastricht 6229 ER
NL
Maastricht 40
Maastricht 6229 ER
NL
Listed location countries
Age
Inclusion criteria
In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
Anorexia Nervosa:
1. Female
2. Have a current diagnosis of Anorexia Nervosa (restrictive subtype)
3. Be a patient at MUMC (or other participating medical centres)
4. Have a BMI between 13 and 18
5. Be able to give informed consent
6. Must be >= 16 years of age
5.7. Able to speak and read Dutch
6.8. Not allergic or intolerant to the liquid stimulidairy drinks
Healthy Control:
1. Female
2. Not have a current or previous (within the past five years) diagnosis of an
eating disorder, anxiety, depression and or OCD.
3. Have a healthy BMI (18.5 - 25).
4. Be able to give informed consent.
4.5. Must be >= 16 years of age
5.6. Able to speak and read Dutch.
6.7. Not allergic or intolerant to the liquid stimuli
Exclusion criteria
For all participants:.
1. Allergies or Intolerances to ingredients contained in the liquid stimuli
2. Left-handedness
3. Existing medically diagnosed neurological disorders
4. Standard fMRI exclusion criteria (e.g., metallic medical devices or
implants, pregnancy, piercings that cannot be removed). See E2 appendix C of
the submitted file.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL69580.068.19 |