The current study is an initial evaluation of the feasibility and effects of exposure therapy in those suffering from ED and comorbid PTSD.
ID
Source
Brief title
Condition
- Other condition
- Eating disorders and disturbances
Synonym
Health condition
Angststoornissen en symptomen (posttraumatische stressstoornis)
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter is decrease of weekly measured PTSD symptom
severity after the onset of exposure therapy compared to baseline.
Secondary outcome
The secondary parameters are to investigate the feasibility of exposure therapy
for PTSD in ED population, to measure the initial effect of exposure therapy on
secondary clinical outcomes and to measure whether the intervention effects are
maintained over time.
Background summary
A frequently occurring comorbidity in eating disorders (ED) is posttraumatic
stress disorder (PTSD). However, controlled studies on treatment of PTSD in ED
are scarce. Expert opinion states concurrent treatment of ED and PTSD, but
research in this field is in its nascent stages.
Study objective
The current study is an initial evaluation of the feasibility and effects of
exposure therapy in those suffering from ED and comorbid PTSD.
Study design
Two separate multiple baseline case series.
Intervention
Participants will receive 10 session exposure therapy for PTSD which will be
added on treatment as usual (TAU) for ED.
Study burden and risks
No significant risks are associated with participation. The burden for the
patients is relatively low, involving additional measurements incorporated in
clinical routine. There are no direct benefits for participants.
Lijnbaan 4
Den Haag 2512VA
NL
Lijnbaan 4
Den Haag 2512VA
NL
Listed location countries
Age
Inclusion criteria
Study 1:
- Female outpatients with anorexia nervosa, or otherwise specified feeding or
eating disorder with anorexia nervosa symptoms (atypical AN) and posttraumatic
stress disorder diagnosis according to DSM-5
- Age 18-65
- Body Mass Index >=15
- Informed consent
- Enrollment in outpatient eating disorder treatment
Study 2:
- Female outpatients with bulimia nervosa, binge eating disorder, otherwise
specified feeding or eating disorder with bulimia nervosa or binge eating
disorder symptoms and posttraumatic stress disorder diagnosis according to DSM-5
- Age 18-65
- Body Mass Index >=15
- Informed consent
- Enrollment in outpatient ED treatment
Exclusion criteria
Study 1:
- Current PTSD treatment
- Other concurrent psychological treatment during the duration of the study
than the studied intervention of exposure therapy and TAU for ED.
- DSM-5 diagnosis of BN, BED, OSFED with BN or BED symptoms, Avoidant
Restrictive Food Intake Disorder, night eating syndrome or purging disorder
- Psychotic disorder
- Medical instability (hospital admission required) or pregnancy
- Changes in psychotropic medication in the two months prior to inclusion
- High risk of suicidality in the last two months (High suicidality score on
MINI-plus and a suicide attempt in the past 6 months)
- Severe non-suicidal self-injury (NSSI) in the last two months (hospital
referral
required)
- Insufficient proficiency in the Dutch language
- Alcohol or drug dependency in last two months
- Cognitive impairment (estimated IQ < 70)
Study 2:
- DSM-5 diagnosis of AN, OSFED with AN symptoms, Avoidant Restrictive Food
Intake Disorder, night eating syndrome or purging disorder
- Current PTSD treatment
- Other concurrent psychological treatment during the duration of the study
than the studied intervention of exposure therapy and TAU for ED.
- Psychotic disorder
- Medical instability (hospital admission required) or pregnancy
- Changes in psychotropic medication in the two months prior to inclusion
- High risk of suicidality in the last two months (High suicidality score on
MINI-plus and a suicide attempt in the past 6 months)
- Severe non-suicidal self-injury (NSSI) in the last two months (hospital
referral
- required)
- Insufficient proficiency in the Dutch language
- Alcohol or drug dependency in last two months
- Cognitive impairment (estimated IQ <70)
Design
Recruitment
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL73138.058.20 |