To get more insight in: *diagnostic and classification criteria for hand OA and its subsets*the association between certain risk factors and hand OA*risk factors for the development and clinical outcome of hand OA*the utility of radiographs and MRI…
ID
Source
Brief title
Condition
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
This is an descriptive study:
1. Expositions of interest are: age, sex, profession, hand strength,
familial/genetic factors, overweigth, symptoms, findings from physical
examination, radiological variables, like joint space narrowing, osteophytes,
erosions, and MRI variables, like bone marrow lesions, effusion
2. Outcomes are: diagnosis hand osteoarthritis, disease course, both clinically
as well as radiologically, over time, use of certain treatment modalities
(painkillers, splints, etc.)
3. Determinants going together with different sub-sets of hand osteoarthritis,
like erosions, nodes, thumb base involvement, can be used as exposition as well
as outcome in the study.
Secondary outcome
not applicable
Background summary
Osteoarthritis (OA) of the hands is one of the most prevalent musculoskeletal
diseases, leading to pain in and around affected joints, to swelling,
stiffness, deformity and gradual loss of function. However knowledge concerning
this disease is still lacking, especially with respect to:
*the diagnostic and classification criteria for hand osteoarthritis and its
subsets
*the association between certain risk factors and hand osteoarthritis
*risk factors for development and clinical outcome in hand osteoarthritis
*the utility of radiographs and MRI in hand osteoarthritis
*the association between hand osteoarthritis and osteoarthritis of the large
joints.
This lack in knowledge hampers optimal patient care.
Currently only symptom modification (like paracetamol, thumb base splint) is
available in hand osteoarthritis, but no disease modifying osteoarthritis drugs
(DMOASDs). The search for DMOADs is an important objective in hand
osteoarthritis research, for which more insight in pathophysiology and clinical
course of the disease is of great importance. An additional problem is the
scarce numbers of randomized clinical trials performed in hand osteoarthrits in
the passed decades by lack of clinimetric possibilities.
Study objective
To get more insight in:
*diagnostic and classification criteria for hand OA and its subsets
*the association between certain risk factors and hand OA
*risk factors for the development and clinical outcome of hand OA
*the utility of radiographs and MRI in hand OA
*the association between hand OA and large joint OA.
With the results of the present study care for patients with hand
osteoarthritis will be improved and new targets for therapy may be elucidated
enabling the development of new treatments for hand osteorthritis.
When more knowledge concerning the course and the classification of hand
osteoarthritis is available good randomized clinical trials can be performed
and new treatment modalities investigated.
Study design
Observational inception cohort
Study burden and risks
Within this cohort usual care for patients with hand osteoarthritis will be
evaluated, but now in a standardized way.
In addition a MRI scan of the left and right hand will be made, leading to a
low risk for the patient, since there is no radiation involved and it is very
unlikely that incidentalomas will be detected by a MRI of the hand.
Furthermore the patient has to fill in questionnaires related to osteoarthritis
for which the patient visits the outpatient clinic. This costs the patient some
extra time.
Albinusdreef 2
Leiden 2333 ZA
NL
Albinusdreef 2
Leiden 2333 ZA
NL
Listed location countries
Age
Inclusion criteria
•Symptomatic *primary* hand OA as diagnosed by a rheumatologist from the
outpatient rheumatology clinic of the LUMC
Exclusion criteria
•Any other pathological condition that could explain the existing symptoms,
like tendinitis, carpal tunnel syndrome, surmenage, fibromyalgia, arthritis due
to a primarily inflammatory rheumatic disease.
•*Secondary* OA, including 1) inflammatory joint diseases, like rheumatoid
arthritis, psoriatic arthritis, spondylarthropathies and current sarcoidosis,
2) bone diseases such as osteitis deformans and osteochondritis, 3)
intraarticular fractures, 4) certain metabolic diseases associated with joint
disease such as hemochromatosis, Wilson*s disease and ochronosis, 5) endocrine
disease like acromegaly, 6) major congenital or developmental diseases and bone
dysplasias, 7) major local factors such as hypermobility, 8) severe (tophous)
gout.
•Inability to understand the Dutch language, Additional exclusion criterion
solely for the Bioelectrical Impedance Analyses (BIA) part of the physical exam
(patients who are excluded for the BIA, will not perform this part of the
physical exam, but can still participate in all the other components of
HOSTAS):
- The presence of a pacemaker or subcutaneous cardio defibrillator. ,
Additional exclusion criteria for patients who undergo MRI for the study:
- The presence of metal in the body: pacemaker or subcutaneous cardio
defibrillator, vascular clips on cerebral vessels, metallic splinters in the
eye, not removable listening aid, not removable neurostimulator,
hydrocephaluspump, dentures fixated by magnets, intra-uterine device
- Allergy for MRI contrast agents
- Impaired renal function
- Pregnancy
Design
Recruitment
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
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In other registers
| Register | ID |
|---|---|
| CCMO | NL26201.058.08 |