To investigate whether sweat, tear fluid, saliva and fingermarks can be used as diagnostic tool by determining whether a relation can be found between blood levels and levels found in the four investigated fluids (primary interest: PSA levels,…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
diagnostische bepalingen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- to demonstrate the presence of a compound of interest in blood and sweat,
tear fluid, saliva and fingermarks.
- to determine the amount/levels of that particular compound in blood and
sweat, tear fluid, saliva and fingermarks.
- to investigate whether a relation can be found in the levels of a particular
compound in blood and sweat, tear fluid, saliva and fingermarks.
In this study we start with investigating the PSA levels, hormone levels and
blood group typing.
Secondary outcome
na
Background summary
Diagnostic tests are performed to aid in diagnosis or/and detection of
diseases. In most cases, blood, urine and faeces will be studied on the
presence of certain deviations. Blood draws are an invasive medical treatment
and can cause emotional distress and varying degrees of pain.
If a non-invasive method is available that can be used for diagnostic testing,
it will be a great advance in the medical field. In this study we want to
investigate whether it is possible to use non-invasively acquired body fluids
as diagnostic tool, including sweat, tear fluid, saliva and fingermarks. We
hypothesize that the chemical composition of the four fluids are related to the
chemical composition of blood. If this is true, diagnostic tests can be
performed in these non-invasively acquired body fluids instead of blood.
In a small pilot-study, we investigated the possibilities of using fingermarks
as a diagnostic tool. We were able to detect PSA, LH and FSH in fingermarks.
Also, the blood group type could correctly be determined in fingermarks of
donors of which the blood group type was known.
In this study we want to investigate whether a relation can be found between
blood levels and levels found in sweat, tear fluid, saliva and fingermarks. To
these four fluids as a diagnostic tool, not only the presence of a certain
component, but also the amount of that component is of importance. Blood levels
will be determined using the standard method (LAKC). The blood levels will be
compared with the levels found in sweat, tear fluid, saliva and/or fingermarks.
Since we already know that it is possible to detect PSA and the blood group
type in fingermarks, we want to start this study with determining whether there
is a relation between PSA, FSH, LH, testosteron, IgE and IgG levels and blood
group antigens found in the different fluids, compared to the levels found in
blood. If a relation can be found between PSA levels, hormone levels in blood
and the non-invasively acquired body fluids, we want to expand this study, by
testing also other important and standard diagnostic tests.
If sweat, tear fluid, saliva and/or fingermarks can be used as non-invasive
method for diagnostic testing, it will be of a major impact to the medical
field.
Study objective
To investigate whether sweat, tear fluid, saliva and fingermarks can be used as
diagnostic tool by determining whether a relation can be found between blood
levels and levels found in the four investigated fluids (primary interest: PSA
levels, hormone levels and bloodgroup typing).
Study design
Observational study.
Study burden and risks
The nature of the burden is classified as minimal, considering that subjects
have to donate blood (minimum 1 tube of 5ml, maximum 3 tubes with a total of
15ml). There are no risks.
Meibergdreef 9
1105 AZ Amsterdam 1105 AZ
NL
Meibergdreef 9
1105 AZ Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria for healthy volunteers:
18 years or older and mentally competent.
Inclusion criteria for unhealthy volunteers, they must meet one of the
following criteria:
-Having a disease, systemic, metabolic.
-Psyhiatric, somatic, organic or neurological disorder.
-Use of medication which might effect the immune system
-Known to have abnormal blood values
Exclusion criteria
Healthy volunteers: exclusion criteria:
- Younger than 18 years and mentally incompetent.
-Pregnancy, or presumption of pregnancy
-The use of anticoagulants or having coagulation disorder
-Use of any investigational drug
-Use of somatic medication which may affect the immune system
-Current or recent (<1 year) alcohol or substance abuse
-Current psychiatric disorder or a first degree family member with a major
psychiatric disorder
-Current systemic disease
-Major metabolic disease
-Somatic, organic or neurological disorder, Exclusion criteria unhealthy
volunteers:
- 18 years or younger
- mentally incompetent.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL44989.018.13 |