To investigate the influence of physical activity and dietary factors on the quality of life of colorectal cancer survivors after treatment, and underlying biological mechanisms.
ID
Source
Brief title
Condition
- Malignant and unspecified neoplasms gastrointestinal NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main outcome parameter is (change in) quality of life of colorectal cancer
survivors, and main determinants are (changes in) physical activity and dietary
factors.
Secondary outcome
Secondary study parameters are biomedical, personal, and environmental factors
related to (specific aspects of) quality of life, physical activity, and diet
of colorectal cancer survivors (as depicted in Fig. 1 on p. 12 of the research
protocol).
Background summary
Physical activity and dietary factors have extensively been studied in the
etiology of colorectal cancer, but their role in determining the quality of
life in colorectal cancer survivors has rarely been investigated. With an
estimated 58,000 colorectal cancer survivors in the Netherlands in 2010,
constituting 14% of all cancer survivors, the identification of lifestyle
factors that improve quality of life after the treatment of colorectal cancer
is imperative.
Study objective
To investigate the influence of physical activity and dietary factors on the
quality of life of colorectal cancer survivors after treatment, and underlying
biological mechanisms.
Study design
In a cohort of colorectal cancer survivors, changes in physical activity and
dietary factors in relation to changes in quality of life after treatment will
be studied prospectively. In addition, the proposed research questions will be
studied cross-sectionally in individuals from two to ten years after treatment
of colorectal cancer. In addition, the biological mechanism underlying these
mechanisms will be investigated.
Study burden and risks
Participation in the prospective study involves six separate outcome and
exposure measurements, including questionnaires, self-reported physical
examinations and repeated blood and saliva sampling. To minimize participants*
burden, blood sampling at the hospital from participants included at the MUMC+
will be combined as much as possible with regular hospital visits. For
participants included at the other participating centers, blood samples will be
collected at participants' homes. All other measurements are performed at a
distance by mail, to avoid the risk of coronavirus infection during a home
visit. In the cross-sectional part of the study, similar outcome and exposure
measurements will be performed at a single point in time during a home visit.
The burden for participants is kept at a minimum and risks of participation are
negligible (risk of a bruise with blood sampling). This study will provide new
insight in how physical activity and dietary factors affect quality of life in
colorectal cancer survivors, and the underlying biological mechanisms. This
knowledge will help identify specific factors related to diet and physical
activity to target in the development of lifestyle intervention programs for
colorectal cancer survivors.
Peter Debyeplein 1
Maastricht 6229 HA
NL
Peter Debyeplein 1
Maastricht 6229 HA
NL
Listed location countries
Age
Inclusion criteria
Prospective study:
- Men and women aged 18 years or older;
- Established diagnosis of stage I, II or III CRC, including recurrent CRC.,
Cross-sectional study:
- Men and women aged 18 years or older;
- History of stage I, II or III CRC, including recurrent CRC, for which the
cases concerned received treatment in the preceding 2 to 10 years.
Exclusion criteria
Prospective study:
- Established diagnosis of stage IV CRC;
- CRC survivors with a current home address not in the Netherlands;
- Inability to understand the Dutch language in speech as well as in writing
(e.g. reading disorders or illiteracy);
- Presence of comorbidities that may obstruct successful participation,
including cognitive disorders such as Alzheimer*s disease or aphasia, and
severe visibility or hearing disorders such as complete blindness and/or
deafness. , Cross-sectional study:
- History of stage IV CRC in the preceding 2 to 10 years;
- Former stage I to III CRC cases who are not alive at present;
- CRC survivors with a current home address not in the Netherlands;
- Inability to understand the Dutch language in speech as well as in writing
(e.g. reading disorders or illiteracy);
- Presence of comorbidities that may obstruct successful participation,
including cognitive disorders such as Alzheimer*s disease or aphasia, and
severe visibility or hearing disorders such as complete blindness and/or
deafness.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL38786.068.11 |