This study aims to investigate the validity and reliability of US to measure muscle size and muscle quality in healthy adults compared to MRI/MRS.
ID
Source
Brief title
Condition
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Agreement between US and MRI/MRS in the area of muscle size (expressed in
rectus femoris cross-sectional area) and rectus femoris quality.
Secondary outcome
Agreement between US (curved array transducer) and US (linear array transducer)
in the area of muscle size (expressed in rectus femoris cross-sectional area).
Background summary
Sarcopenia, defined as a progressive loss of muscle mass and function, is a
result of the process of aging and is associated with functional decline and
disability. As poor function of especially thigh muscles is associated with
loss of mobility, the assessment of thigh muscles has become an important
clinical measure for older adults. Currently, Computed Tomography (CT) and
Magnetic Resonance Imaging (MRI) are considered to be the *gold standard* for
the assessment of thigh muscle size and muscle quality. However, high costs,
long scanning times and accessibility are major drawbacks of these techniques.
Because of its non-ionizing nature ultrasound (US) has been suggested to assess
muscle size and muscle quality, but complete understanding about validity and
reliability of ultrasound is lacking.
Study objective
This study aims to investigate the validity and reliability of US to measure
muscle size and muscle quality in healthy adults compared to MRI/MRS.
Study design
To assess validity of US, the participants will be measured with MRI and US
once during a single day. To assess reliability of US, a second US scan will be
performed with a one-week interval.
Study burden and risks
During the study participants will undergo one MRI/MRS and two US scans.
Furthermore, body weight and length will be assessed. The US scans and the
MRI/MRS scan pose no health risks and are proven not to be stressful for the
individual. The most reported side effect of MRI scan is slightly warming of
the body, however this is not considered to be harmful. No side effects of US
scans are known. This study is not expected to cause any additional physical
harm to the subjects* health. Therefore, we consider the burden of these study
measurements to be minimal (about 60 minutes at the first assessment and 30
minutes at the second assessment) and the risk negligible. Participants can
withdraw from the study at any time; this has no consequences for the
participant.
Eyssoniusplein 18
Groningen 9741 CE
NL
Eyssoniusplein 18
Groningen 9741 CE
NL
Age
Inclusion criteria
-Adults aged between 18 and 65 years old.
-Able to understand and speak the Dutch language
Exclusion criteria
-Participants who have a heart pacemaker or implants
-Participants with severe claustrophobia
-Participants who have severe neuromuscular diseases or functional impairments
- Written informed consent
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL51462.042.14 |