In this study, we therefore aim to investigate how trained immunity is systemically regulated in ANCA vasculitis patients and how the degree of trained immunity affects disease activity and severity. A better understanding of these processes…
ID
Source
Brief title
Condition
- Autoimmune disorders
- Vascular disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. What are the differences in the transcriptome of circulating monocytes from
AAV patients when the disease is in remission or when the disease is active
(flares), and how does this differ with the transcriptome of circulating
monocytes from healthy individuals?
2. What are the differences in the epigenome of circulating monocytes from AAV
patients when the disease is in remission or when the disease is active
(flares), and how does this differ with the epigenome of circulating monocytes
from healthy individuals?
3. What are the differences in the cytokine response of circulating monocytes
from AAV patients when the disease is in remission or when the disease is
active (flares), and how does this differ with the response of circulating
monocytes from healthy individuals?
Secondary outcome
1. Are there correlations between the trained immunity profile of circulating
monocytes (identified by transcriptome, epigenetics, and cytokine response) and
the degree of current disease activity in clinical variables of AAV patients?
2. Are there correlations between the trained immunity profile of circulating
monocytes (identified on the basis of the transcriptome, epigenetics, and
cytokine response) and the risk of the occurrence of flares in the future.
3. Are there correlations between the trained immunity profile of circulating
monocytes (identified based on the transcriptome, epigenetics, and cytokine
response) and inflammatory markers in the blood.
Background summary
ANCA vasculitis is an autoimmune disease in which small- to medium-sized blood
vessels are inflamed and anti-neutrophil cytoplasmic antibodies (ANCAs) are
detectable in the serum. ANCA vasculitis can produce a size variety of symptoms
and several organs may be affected, including the lungs, skin and kidneys.
Organ damage, including kidney failure, may result. Dialysis or a kidney
transplant are then the only options for patients.
In ANCA vasculitis, ANCAs in the serum activate neutrophils of the innate
immune system by binding to MPO/PR3 on these neutrophils. However, how the
production of ANCAs comes about and what role other cells of the innate immune
system, such as monocytes and macrophages, play in ANCA vasculitis is still
largely unclear.
In this study, we are investigating trained immunity in ANCA vasculitis
patients. Trained immunity is a form of memory of innate immune cells, which
causes higher inflammatory activity upon stimulation. Our hypothesis is that
trained immunity may lead to activation of the immune response in ANCA
vasculitis patients and contribute to disease flare.
Study objective
In this study, we therefore aim to investigate how trained immunity is
systemically regulated in ANCA vasculitis patients and how the degree of
trained immunity affects disease activity and severity. A better understanding
of these processes contributes to the discovery of new targets for therapy for
ANCA vasculitis patients.
Study design
This is a clinical observational study.
Study burden and risks
This is an observational study in which participants complete a questionnaire,
have their blood pressure measured and donate body fluids (urine and blood), ln
our view, there are no risks associated with this. The burden for participation
in this study is minimal and consists of a 1-
hour visit to our outpatient clinic.
Geert Grooteplein Zuid 8
Nijmegen 6525 GA
NL
Geert Grooteplein Zuid 8
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
Age between 18 and 70 years old.
Positive AAV diagnosis.
Exclusion criteria
Lack of informed consent
Current infection
CKD stage 5 or dialysis
Pregnancy
Active cancer
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL84182.091.23 |