The primary objective of this study is to obtain insight in how the light spectra may regulate eye growth and control emmetropization by studying the choroidal thickness in human eyes after exposure to monochromatic light conditions. Based on…
ID
Source
Brief title
Condition
- Vision disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome is change in choroidal thickness during monochromatic light
exposure.
Secondary outcome
Secondary outcomes are change in choroidal thickness between different light
conditions (different wavelenghts) and change in axial length before and after
light conditions.
Background summary
The prevalence of myopia is rising rapidly throughout the world, with 10% of
the world population expected to be highly myopic (<-6 diopters) by 2050.
Individuals with high myopia have a 1 in 3 chance to develop visual impairment
by age 75 years. Therefore, myopia will become a vast social (economic) burden
in the future. Animal research has shown that monochromatic light slows
myopization and could hypothetically be used as a preventive therapy.
Study objective
The primary objective of this study is to obtain insight in how the light
spectra may regulate eye growth and control emmetropization by studying the
choroidal thickness in human eyes after exposure to monochromatic light
conditions. Based on previous literature and earlier experiments we conducted
in zebra fish, we expect red (633 nm) and blue (423 nm or 463 nm) light to
cause transient choroidal thickening.
Study design
After signing written consent and filling-out a questionnaire, participants are
placed in a dark room (<10 lux) for 10 minutes. Afterwards, the room is
monochromatically lit for 30 minutes. We conduct ocular measurements at the
start, during, and at the end of the light exposure (5-minute interval). We
repeat this a total of 5 times with different colors.
Intervention
Participants are placed in a dark room (<10 lux) for 10 minutes, after which
they are exposed to monochromatic (single wavelength) light
for 30 minutes. We repeat this process several times for different wavelengths,
each time preceded by 10 minutes of darkness.
We use commercially available LEDs, verified by handheld photospectrometer to
emit light of similar irradiance.
Study burden and risks
We expect the burden of participation to be negligible. There are no invasive
or harmful measurements (ocular measurements are non-contact and use no
radiation). During the experiment, there may be a very small discomfort from
being placed in a monochromatically lit room. No lasting side-effects are
expected or previously mentioned in the literature. The experiment is conducted
in one site visit. The questionnaire contains no burdensome questions.
Doctor Molewaterplein 40
Rotterdam 3015 GD
NL
Doctor Molewaterplein 40
Rotterdam 3015 GD
NL
Listed location countries
Age
Inclusion criteria
Age between 18 to 35 years old.
No caffeine or alcohol consumption 10 hours prior to the start of the
experiment.
Exclusion criteria
Ocular pathology or systemic pathology with ocular manifestations.
Factors known to alter the circadian rhythm or sleep.
Pregnancy, breast feeding.
Smoking.
Previous myopia control treatments.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL83619.078.23 |