To assess the feasability of measuring placental perfusion by measuring the placental and uterine blood vessels and maternal haemodynamic function in women with singleton pregnancies between 14- and 16-weeks*gestational age.
ID
Source
Brief title
Condition
- Placental, amniotic and cavity disorders (excl haemorrhages)
- Vascular hypertensive disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The assessment of the reproducibility of measuring the placental perfusion in
women with singleton pregnancies between 14- and 16-weeks*gestational age
Secondary outcome
1. To assess whether it is possible to repeatedly measure the blood
velocity and diameter of the uterine arteries and veins, and umbilical arteries
and vein.
2. What are the differences in measurements between the two umbilical arteries?
3. Does a relation between the uterine artery and vein flow exist?
4. Does a relation between the umbilical arteries and vein flow exist?
5. The assessment of intra-observer variability.
Background summary
The placenta is the connection between foetal and maternal blood flow. The
placenta is thus an essential organ that delivers the nutrition needed for the
growth of the foetus. The uterus, the organ that houses the placenta, undergoes
changes from the moment of conception and throughout pregnancy to accommodate
the needs of the placenta and the foetus. There are many maternal and foetal
pathologies that are related to the mismatch between blood flow needs of the
foetus and the ability to provide the adequate blood flow from the uterus and
placenta. This leads us to our current search for an accurate and reproducible
way to measure placental perfusion.
Study objective
To assess the feasability of measuring placental perfusion by measuring the
placental and uterine blood vessels and maternal haemodynamic function in women
with singleton pregnancies between 14- and 16-weeks*gestational age.
Study design
pilot study, prospective cohort.
Study burden and risks
Patients are burdened by having an extra visit to the outpatient clinic. During
this visit, the participants would spend approximately 1 hour in a horizontal
position to be able to complete all measurements. Added benefits associated
with this study is the possibility to have an extra moment to see the baby by
ultrasound.
De Run 4600
Veldhoven 5504 DB
NL
De Run 4600
Veldhoven 5504 DB
NL
Listed location countries
Age
Inclusion criteria
- Age 18 years or higher
- Between 14-16 weeks gestation
- Placenta anterior
- BMI <30 kg/m2
- Ability to give consent
- Adequate mastery of Dutch or English language
Exclusion criteria
- Non-intact pregnancy
- Vanishing twin
- Multiple gestations
- Congenital or anatomical anomalies
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL83681.015.23 |