The purpose of this study is to examine the effect of exogenous ketone body supplementation on carbohydrate metabolism during exercise.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
This study will evaluate the effect of exogenous ketone mono-ester supplementation on endogenous and exogenous carbohydrate metabolism during exercise
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Comparing exogenous glucose oxidation during exercise between the ketone
monoester and placebo conditions
Secondary outcome
- Endogenous glucose disappearance rate
- Exogenous glucose disappearance rate
- Total glucose disappearance rate
- Exogenous glucose appearance rate
- Endogenous glucose appearance rate
- Total glucose appearance rate
- Plasma glucose enrichments
Tertiary
- Total carbohydrate oxidation indirectly by using traditional stoichiometric
calculations of carbohydrate oxidation
- Plasma glucose, insulin, lactate, glycerol, and ketone body concentrations
(including area under the curve) following drink ingestion
- Exercise economy
- Mean exercise heart rate
- Data for subject characteristics (i.e. age, weight, height, peak oxygen
uptake)
Background summary
Recently, there has been a re-emerging interest in the role of ketone bodies in
exercise metabolism. Ketone bodies can serve as an important energy substrate
under certain conditions, such as starvation, and can modulate carbohydrate and
lipid metabolism. However, the extent to which acute ketone body
supplementation regulate skeletal muscle bioenergetics and substrate metabolism
during prolonged endurance-type exercise remains to be determined. Therefore,
it is of importance to perform direct measures of substrate utilization after
supplementation with ketone bodies. With respect to carbohydrate use, neither
endogenous nor exogenous carbohydrate oxidation have been determined. Thus,
direct measures of endogenous and exogenous carbohydrate oxidation will help
clarify the effects of acute ketone body supplementation on substrate
oxidation.
Study objective
The purpose of this study is to examine the effect of exogenous ketone body
supplementation on carbohydrate metabolism during exercise.
Study design
Randomized, crossover, and double-blind
Intervention
The acute interventions will involve ingestion of carbohydrates with either a
ketone monoester supplement before (0.35 g/kg body mass) and throughout (0.20
g/kg body mass per hour) the 3-hour exercise session or flavour-matched
ketone-free placebo.
Study burden and risks
Participants will be required to report to the laboratory for a total of 3
visits, comprised of 1 screening visit (~2 h), and 2 experimental visits (each
~6 h). Participants will have to record their diet and activity patterns for 72
h prior to the 2 experimental visits and duplicate these patterns before the 2
experimental visits. The potential risks and discomforts inherent to the
exercise testing procedure during each visit are minimal and are similar to
those associated with any form of strenuous physical activity including
fatigue, fainting, abnormal blood pressure, etc. Subjects will provide 10 blood
samples during each experimental visits (20 total for the study). Insertion of
the catheters in a vein is comparable to a normal blood draw and the only risk
is a small local hematoma.
Universiteitssingel 50
Maastricht 6229 ER
NL
Universiteitssingel 50
Maastricht 6229 ER
NL
Listed location countries
Age
Inclusion criteria
- 18-50 years of age
- Trained cyclist/triathlete ((VO2peak > 55 ml/kg/min for males and >48
ml/mg/min for females)
- Healthy as per medical history and investigator*s/physician*s judgement
- Having given written informed consent
Exclusion criteria
- Use of medication that could impact study outcomes and/or interfere with the
expected mechanism of action of ketone supplements (e.g. Chronic use of gastric
acid suppressing medication, statins, corticosteriods)
- Smoking
- Diagnosed acute or chronic medical conditions that, in the opinion of the
investigator, could impact study outcomes (e.g. Diabetes mellitus)
- Diagnosed musculoskeletal disorders
- Adhering to a carbohydrate restrictive diet
- Participation in another study at the same time
- Blood donation in the 2 months before the first experimental trial
- Plasma donation in the 2 weeks before the first experimental trial
- Males: VO2peak <55 ml/min/kg body mass
- Females: VO2peak <48 ml/min/kg body mass
- Females: pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL83622.068.23 |
| Other | will be done after METC approval |