Primary: - Examine longitudinal developmental trajectories of structural and functional brain metrics in relation to genetic, clinical, psychological, environmental, and cognitive information in familial high-risk offspring and control children (…
ID
Source
Brief title
Condition
- Other condition
- Schizophrenia and other psychotic disorders
Synonym
Health condition
psychische stoornissen: bipolaire stoornis
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Brain volume, cortical thickness, cortical surface, curvature/gyrification
metrics (global measures and local regions) from T1 weighted images.
- Fractional anisotrophy, mean diffusivity, axial diffusivity, radial
diffusivity (per fiber and voxelbased) from DTI images.
- Brain activation during resting state (per region and voxelbased) from rsfMRI
images.
- Graph theory metrics from FA (DTI) and resting state brain activation
(rsfMRI).
Secondary outcome
The following variables are seen as possible confounding or modifying factors:
- sex and age
- age of onset parental and offspring disorder
- marital and/or household status of parents
- income and educational level of parents
- parental psychosis, depression, and/or mania diagnoses and symptoms
- medication use
- handedness
Background summary
A family history of mental illness is the most important known risk factor for
the development of mental health problems. Child, adolescent and young adult
offspring of parents with a severe mental illness (i.e. schizophrenia, bipolar
disorder, depression) offer a unique opportunity to further the research into
intergenerational transmission, as in this group the likelihood of mental
health problems is increased.
Brain structural and functional metrics and their developmental trajectories
have been hypothesised to underlie the transmission of mental illness. Here we
propose to again approach the families from the Dutch Bipolar and Schizophrenia
Offspring Study (DBSOS, Dutch name: BRIDGE [BRain Imaging, Development and
Genetics]). BRIDGE is an ongoing prospective cohort study, investigating the
development of brain, genetics, cognitive functioning, and environment, that
contribute to risk and resilience in offspring with at least one parent with
schizophrenia (SZo) and offspring with at least one parent with bipolar
disorder (BDo).
Study objective
Primary: - Examine longitudinal developmental trajectories of structural and
functional brain metrics in relation to genetic, clinical, psychological,
environmental, and cognitive information in familial high-risk offspring and
control children (BRIDGE cohort only).
- Investigate the relationship between parental and family characteristics and
differences (or overlap) in maternal, paternal and child brain metrics and how
these differ between at risk families and control families (pooling across
European cohorts with the FAMILY consortium: https://family-project.eu/).
Secondary: - assess the role of cognitive, environmental, behavioural, and
clinical characteristics on the brain imaging findings.
Study design
Observational study, longitudinal study, family (triad/dyad) study.
Study burden and risks
Study participation involves one visit to the Erasmus MC to undergo an MRI scan
of maximally one hour. MRI is a non-invasive technique (i.e., nothing is
inserted into the body). However, the CCMO marked MRI as an invasive technique
to heighten the safety regulations. There are no known risks associated with
MRI acquisition, so there is no need for special preparation for the subject on
top of the Erasmus MC standard procedure. The data are primarily used for
research purposes. However, a radiologist will provide a neurodiagnostic
evaluation. When the specialist finds that medical treatment is indicated, then
the subject will be notified. Subjects may become anxious during the scan. The
participant can communicate this by means of a push button, and he/she will be
taken out of the scanner.
The risk assessment for participation to this study is minimal. Subjects will
experience no direct benefits from our study. In the long run, increased
understanding of the aetiology and pathophysiology of schizophrenia and bipolar
disorder may contribute to diagnosis, early detection and/or prediction of
treatment outcome.
Wytemaweg 8
Rotterdam 3015CN
NL
Wytemaweg 8
Rotterdam 3015CN
NL
Listed location countries
Age
Inclusion criteria
Previously-included offspring: All offspring who participated in the BRIDGE
cohort are eligible for inclusion in this MRI study. Offspring will now be 14
years and older. The only other inclusion criterion is ability to provide
informed consent.
Parents: All biological parents of offspring who participated in the BRIDGE
cohort are eligible for inclusion in this MRI study. The only other inclusion
criterion is ability to provide informed consent.
Newly-included offspring: All biological offspring who did not previously
participate in the BRIDGE cohort are eligible for inclusion in this MRI study.
As this will be their first assessment, subjects will have to satisfy the
following criteria in order to participate in the study:
-from 8 years and older
-provide written informed consent (by child and/or parents)
-Dutch speaking
- IQ > 70
Exclusion criteria
Previously-included offspring, newly-included offspring, and parents:
- contraindication for MRI (including claustrophobia, a cardiac implantable
electronic device, ferromagnetic metal implants, piercing (in some cases),
tattoos (in some cases)) (Ghadimi & Sapra, 2022);
- not having given permission to be approached for further research during an
earlier assessment.
- history of closed- or open-head injury
- history of neurological illness
- major medical history
- history of epilepsy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL82802.078.22 |