In-vivo validation of protein makers in minimal invasive skin biopsies from persons with blunt injuries in different time periods.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
letsel - bloeduitstortingen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Expression of protein markers in superficial layers of the skin (epidermis and
superficial dermis), detected and measured by immunohistochemical analysis in
skin biopsies from bruises as follows:
- the quantity of the protein marker or an (intensity) score reflecting the
presence/ absence of the protein marker and,
- the cellular location (keratocytes, fibroblasts or extracellular matrix) of
each marker
Secondary outcome
N/A
Background summary
Evidence-based methods to date injury, especially in living subjects, are
lacking.
Developing an evidence based method for injury dating will improve forensic
medical expertise and be greatly beneficial for the legal process in
fact-finding of crimes.
Study objective
In-vivo validation of protein makers in minimal invasive skin biopsies from
persons with blunt injuries in different time periods.
Study design
Cross-sectional observational study
Intervention: minimal invasive skin biopsies from persons with bruises in
different time periods
Study burden and risks
This study involves an once-off skin biopsy, no additional visits are needed.
The health risk of the skin biopsy is low, it is an minimal invasive procedure
with little discomfort and minimal medical risks.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
• Age 18 years or older
• Competent
• Sufficient Dutch/ English proficiency
• Visible bruises caused by external force
• Clear knowledge and preferably proof of the date and time the injury has been
sustained
• Informed consent to undergo a skin biopsy and donate the material
Exclusion criteria
• Location of the bruise in the face/ hands/ feet
• Pre-existing inflammatory skin disorders such as psoriasis, SLE and dermatitis
• History of keloid formation or hypertrophic scar formation
• Relevant medication use such as anticoagulation drugs
• Skin injury such as lacerations
• Underlying fractures of bone
• Sexual assault
• Serious emotional/ mental disturbance
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL81502.018.23 |