The aim of this research proposal is to examine the effect of different ISIs on mTc-MEPs.Primary research question: What is the effect of different interstimulus intervals (ISIs) on mTc-MEP thresholds, peak-to-peak amplitudes, and area under the…
ID
Source
Brief title
Condition
- Spinal cord and nerve root disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are mTc-MEP motor thresholds, amplitudes, and AUC of
the tibialis anterior (TA) and abductor hallucis (AH) muscles, associated with
different ISI stimulations (1, 2, 3 and 4 ms).
Secondary outcome
1. Variability will be based on peak-to-peak amplitudes
2. Optimal ISI for the 2 different stimulators will be determined based on the
primary outcome variables.
3. Time and amplitudes will be used to answer this research question.
Background summary
Intraoperative neurophysiological monitoring (IONM) is used to detect and
prevent neurological damage during surgeries with a high risk of neurological
damage. Muscle transcranial electrical stimulation motor evoked potential
(mTc-MEP) monitoring is an IONM modality that is commonly used during spinal
surgery. Stimulation parameters, such as the interstimulus interval (ISI),
influence the characteristics of mTc-MEPs. The aim of this research proposal is
to examine the effect of different ISIs on mTc-MEPs. Optimal ISI is defined as
the ISI that can generate MEPs with the lowest motor thresholds or the highest
peak-to-peak amplitudes.
Study objective
The aim of this research proposal is to examine the effect of different ISIs on
mTc-MEPs.
Primary research question:
What is the effect of different interstimulus intervals (ISIs) on mTc-MEP
thresholds, peak-to-peak amplitudes, and area under the curve (AUC)?
Secondary research questions:
1. What is the influence of different ISIs on the variability of mTc-MEP
amplitudes and thresholds?
2. Is the optimal ISI different for constant current (LMU hospital Munich) and
constant voltage (UMCG) stimulators?
3. Does the optimal ISI shift over time?
Study design
Prospective observational study.
Study burden and risks
The total anesthesia time will be extended by maximal 20 minutes per patient.
Hanzeplein 1
Groningen 9713GZ
NL
Hanzeplein 1
Groningen 9713GZ
NL
Listed location countries
Age
Inclusion criteria
The patient will undergo a surgery with spinal mTc-MEP monitoring
Exclusion criteria
The patient had pre-existing muscle weakness in the AH or TA muscles
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL82612.042.22 |