Assess nutrition-related biomarkers in plasma and urine samples at ICU admission
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Herstel na kritische ziekte
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Biomarker status in blood and urine between baseline
Markers general health: hemoglobin (Hb), mean corpuscular volume
(MCV), glucose, c-reactive protein (CRP), thyroid stimulating hormone
(TSH), creatinine + glomerular filtration rate (eGFR), alanine
aminotransferase (ALAT), urea, albumin, total protein, lipid profile
Micronutrients: potassium, calcium, sodium, vit B11, vit B1, vit
B6, vit B12, vit D, Vit C, ferritin, magnesium, chloride, phosphorus
Secondary outcome
- Total number of micronutrient deficiencies at baseline
- Dietary intake at baseline
Measured with: dietary intake diary
- Objective nutritional status and muscle thickness at baseline
Measured with: bioimpedance analysis, ultrasound assessment of
quadriceps muscle layer thickness QMLT
Background summary
A significant proportion of patients admitted to the Intensive Care Unit (ICU)
is unable to fully recover, even when the initial cause of their illness has
been treated. Inadequate dietary intake prior to admission and during the
recovery phase may leave patients in a frail physical state, limiting
rehabilitation potential. Commonly used methods to assess nutritional intake
and nutritional status are highly impacted by various disease-related
confounders and reporting bias. We hypothesise that a combined assessment of
biomarkers in plasma and urine may provide a more accurate overview of
nutritional status before and after ICU-admission.
Study objective
Assess nutrition-related biomarkers in plasma and urine samples at ICU
admission
Study design
Cross-sectional study
Study burden and risks
In addition to standard care ICU treatment, blood and urine samples will be
collected in the first 24 hours of ICU-admission in all patients. In addition,
ultrasound measurement of the upper leg will be conducted within 72 hours of
admission. When feasible, patients will be asked to complete a dietary intake
diary during admission.
Henri Dunantweg 2
Leeuwarden 8934AD
NL
Henri Dunantweg 2
Leeuwarden 8934AD
NL
Listed location countries
Age
Inclusion criteria
Admission to the Intensive Care Unit
Able to read and understand Dutch
Exclusion criteria
Comorbidity highly affecting gut absorption (e.g. post-bariatric surgery)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL83298.099.22 |
| Other | Onderzoek wordt geregistreerd na toestemming RTPO |