To quantify the strength and direction of interactions between important respiratory virus infections in young children
ID
Source
Brief title
Condition
- Viral infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
(Co-)occurrence, timing and virus species of respiratory infection as detected
by PCR analysis of weekly nasal swab specimens.
Secondary outcome
Presence and severity of respiratory and systemic symptoms compatible with
virus infection. Occurrence of acute respiratory illness (ARI) is based on
daily symptom monitoring.
Background summary
Prevention of virus induced acute respiratory infection (ARI) is a public
health priority. As different respiratory virus infections can interact with
each other, prevention of one virus by vaccination may influence occurrence of
other virus infections. In this project, we will quantify such interactions
between respiratory viruses by longitudinally studying a cohort of young
children.
Study objective
To quantify the strength and direction of interactions between important
respiratory virus infections in young children
Study design
This is a prospective observational cohort study
Study burden and risks
This study is observational in nature. There will be no direct benefit to
research participants. The study includes biological sampling. The results of
the tests done on these samples may not contribute to improving the
participant*s health. Minimal inconvenience and discomfort to the participant
may arise from study visits and biological sampling.
Heidelberglaan 100
Utrecht 3584 CX
NL
Heidelberglaan 100
Utrecht 3584 CX
NL
Listed location countries
Age
Inclusion criteria
Age older than 6 weeks and less than 4 years
AND
1) have older siblings or 2) attend daycare.
AND
Live within 30 minutes drive from UMCU (by car) and have access to a fever
thermometer
Exclusion criteria
recurrent respiratory tract infections and are treated with antibiotic
profylaxis
OR
known immunodeficiency
OR
chronic lung disease that increases susceptibility to infection (e.g. cystic
fibrosis)
OR
congenital anomalies of the airways
Parents/guardians have insufficient comprehension of Dutch language (all study
communication and questionnaires are in Dutch language)
A sibling already participating in the study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| ClinicalTrials.gov | NCT05318235 |
| CCMO | NL78424.041.21 |