To carry out a large-scale replication study of a previous study that reported that a single dose of intranasal oxytocin (i.e. oxytocin vapour inhaled through the nose) increased trust between humans.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
psychologische functies
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The amount of money transferred from one human (*the investor*) to another
human (*the trustee*); a proxy measure of interpersonal trust during a
well-validated investment game.
Secondary outcome
Correlations among the amount of money invested into the trustee and a range of
psychological variable assessed using validated rating instruments (including
reward and punishment sensitivity, extraversion, propensity to trust others).
Background summary
The neuropeptide oxytocin has been linked to a range of human social functions,
including empathy, bonding, and interpersonal trust (the degree to which humans
trust each other). In recent years mixed results have been reported about the
link between oxytocin and interpersonal trust.
Study objective
To carry out a large-scale replication study of a previous study that reported
that a single dose of intranasal oxytocin (i.e. oxytocin vapour inhaled through
the nose) increased trust between humans.
Study design
A randomized double-blind placebo-controlled between subjects design using two
groups: a group receiving a single dose of oxytocin (Syntocinon 24 I/U; n=110),
and a group receiving placebo (saline solution; n=110)
Study burden and risks
The participation risks are minimal. Study participation consists of two
sessions. Session 1 is a digital 1-hour session that can be completed at the
participant*s convenience, and does not require a laboratory visit. There are
no known risks associated with this session. Session 2 is a max. 2-hour
laboratory session during which two participants play an investment game. Prior
to playing the game, participants inhale a nasal spray containing Syntocinon or
placebo. Syntocinon is a very well-tolerated and safe nose spray containing
oxytocin, and produces no to mild (headache, dizziness) side-effects, even when
administered repeatedly, in higher doses, or is used for prolonged periods of
time. The use of a well-established low dose, the availability of a medical
expert, the short half-life of the spray, and a number of risk minimization
strategies (see section 13) ensure that participation risks are minimal.
Vijverdalseweg 1
Maastricht 6226NB
NL
Vijverdalseweg 1
Maastricht 6226NB
NL
Listed location countries
Age
Inclusion criteria
Male
Age 18-32
Exclusion criteria
Psychiatric (including substance abuse/dependence) or neurological disorder
Current treatment by a psychologist or psychiatrist for mental health-related
problems
Current use of psychoactive medication for mental health-related problems:
antidepressants, antipsychotics, benzodiazepines, anxiety medication,
neuroleptics, anticonvulsants, stimulants
Latex allergy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL74615.068.20 |