The objective of this study is to investigate the coordination and development of speech articulation of patients who will undergo surgical treatment for oral cancer longitudinally and whether individual differences in the reliance on auditory or…
ID
Source
Brief title
Condition
- Head and neck therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are the articulatory trajectories of the tongue, the
lips and the jaw during the production of speech of patients and controls as
measured by electromagnetic articulography (EMA). The amplitude, velocity and
stiffness of these movements will be analysed. In addition, compensation to
auditory and tactile feedback perturbation will be studied.
Secondary outcome
Acoustic measures of speech (e.g., intensity, speech rate, and spectral moments
of specific sounds).
Background summary
Among all cancers, treatment of oral cancer has one of the highest risks in
developing problems with important functions like speaking and swallowing.
Problems with speaking, or articulating well, can have a negative impact on the
quality of life of patients as it complicates communication. Moreover, patients
rank the ability to 'speak clearly' as one of their top-5 priorities. Yet, the
speech problems induced by oral cancer treatment are not well understood,
especially in terms of quantitative changes in articulation. This results in
the near absence of guidelines for speech therapy post-treatment. The proposed
research will shed more light on the articulatory changes. With its
longitudinal design and a focus on compensatory strategies, the results of this
study will become available to clinicians and speech therapists, who will be
able to use the results of the study to set up evidence-based guidelines for
speech therapy or minimise the negative effects during treatment.
Study objective
The objective of this study is to investigate the coordination and development
of speech articulation of patients who will undergo surgical treatment for oral
cancer longitudinally and whether individual differences in the reliance on
auditory or tactile information can predict the success of speech compensatory
strategies.
Study design
The study in question is a longitudinal prospective study with an additional
cross-sectional cohort. Data will be collected using both acoustic (i.e.,
speech recordings) and articulatory methods (electromagnetic articulograhphy).
Participants will perform several speech tasks, some under normal feedback
conditions (i.e., what they hear or feel in their mouth when speaking will not
be changed), others while the auditory or tactile feedback is altered. During
these tasks, the speech signal will be recorded with a microphone while the
participant will be wearing headphones. Articulatory trajectories will be
recorded using electromagnetic articulography (EMA) in normal conditions and
with (pink) noise. In parallel, the speech signal will also be recorded with a
microphone. The data from the oral cancer patients will be compared to
non-speech disturbed controls and to earlier evaluation points.
Study burden and risks
No known risks or benefits are associated with participating in this study.
Hanzeplein 1
Groningen 9713GZ
NL
Hanzeplein 1
Groningen 9713GZ
NL
Listed location countries
Age
Inclusion criteria
1. Diagnosed with or treated for a T1 or T2 tumor in the oral cavity
2. At least 18 years old and able to provide informed consent
3. Native speaker of Dutch
4. Has nog been treated for oral cancer before
Exclusion criteria
1a. Recurrence of disease (for patients)
1b. Treated for oral cancer (for healthy controls)
2. Speech problems (e.g., stuttering)
3. Problems with sight or hearing that impede reading or understanding
instructions. When glasses or a hearing aid
resolve these problems, then participants are not excluded.
4. Neurological or psychological disorders (e.g., stroke)
5. Non-removable metal in, on or around the head (piercings, braces, pacemaker,
electrodes)
6. Self-reported signs of depression
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| ClinicalTrials.gov | NCT05876247 |
| CCMO | NL79242.042.21 |