To measure cardiac output at various levels of Positive End Expiratory Pressure (PEEP).
ID
Source
Brief title
Condition
- Cardiac disorders, signs and symptoms NEC
- Lower respiratory tract disorders (excl obstruction and infection)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cardiac output at different levels of PEEP
Secondary outcome
Secondary objectives included a) assessment of right ventricular parameters at
different levels of PEEP, b) relationship of changes in primary outcome to
respiratory mechanics and c) influence of phase of illness on these parameters.
Background summary
Due to their shared intrathoracic cavity the heart and lungs are anatomically
closely related. Physiologically their combined functions provide adequate
oxygen delivery to the entire body. Positive pressure ventilation, a regular
intervention in the paediatric intensive care unit, influences intrathoracic
pressures. Our understanding of the impact this pressure change induces is
mostly based on animal studies and adult data, due to the invasive nature of
diagnostic tests. Technological advances in the use of ultrasound have made it
a bedside tool for the acute care physician. By using this technology, we will
address the paucity in data on paediatric cardiopulmonary interactions.
Study objective
To measure cardiac output at various levels of Positive End Expiratory Pressure
(PEEP).
Study design
This is a prospective observational study without invasive measurements in a 20
bed tertiary paediatric intensive care facility at the Beatrix Children*s
Hospital/University Medical Centre Groningen. The study will start March 1,
2021 and is completed by June 30, 2022
Intervention
Adjustment of Positive End-Expiratory Pressure (PEEP) at different levels.
Study burden and risks
Measurements will be taken solely by non-invasive means. Ultrasound is a
proven, harmless diagnostic used for routine clinical practice throughout the
hospital. Hence burden for the patient will be minimal.
Hanzeplein 1
Groningen 9713GZ
NL
Hanzeplein 1
Groningen 9713GZ
NL
Listed location countries
Age
Inclusion criteria
All patients aged 0 - 5 years who are mechanically ventilated for at least 24
hours
Exclusion criteria
- Physical restrains (e.g. syndromal disorders) making it impossible to obtain
required images
- Aortic stenosis
- Congenital heart defects resulting in a single ventricle physiology.
- Patients on ECMO
- Patients who are haemodynamically unstable
- premature birth with gestational age corrected for post-conceptional age less
than 40 weeks
- congenital or acquired neuromuscular disorders
- congenital or acquired central nervous system disorders with depressed
respiratory drive
- severe traumatic brain injury (i.e. Glasgow Coma Scale <8)
- chronic lung disease
- severe pulmonary hypertension
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL76731.042.21 |