Studies have shown that generation of lung cells from human pluripotent stem cells is possible. The present study aims to develop cell cultures, such as 3D mini lung structures from skin cells from subjects with ILD and/or their family members. The…
ID
Source
Brief title
Condition
- Other condition
- Lower respiratory tract disorders (excl obstruction and infection)
Synonym
Health condition
ILD
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
not applicable
Secondary outcome
not applicable
Background summary
Currently, the etiopathogenesis of most interstitial lung diseases (ILD) is
still unknown and the treatment options are limited. Human in vitro tissue
systems that faithfully reproduce in vivo ILD lung tissue could facilitate
investigation of disease mechanisms and the development of effective therapies
for this devastating disease.
Study objective
Studies have shown that generation of lung cells from human pluripotent stem
cells is possible. The present study aims to develop cell cultures, such as 3D
mini lung structures from skin cells from subjects with ILD and/or their family
members. The generated cell culturs will be used for research by researchers of
renowned laboratories and the St Antonius hospital.
Study design
A small skin biopsy from subjects with ILD and/or their family members will be
used to develop cell cultures
Study burden and risks
a little scar from the skin biopsy, colouring of the skin (bruise), and a small
chance of a little bleeding.
Koekoekslaan 1
Nieuwegein 3435CM
NL
Koekoekslaan 1
Nieuwegein 3435CM
NL
Listed location countries
Age
Inclusion criteria
ILD and/or their family members
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL58379.100.16 |