in this study we aim to investigate incidence of eleven Chlamydia species in deep respiratory secretionss from patients with community acquired pneumonia. The additional value of faecal samples will be investigated. In addition, we aim to…
ID
Source
Brief title
Condition
- Chlamydial infectious disorders
- Respiratory tract infections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary: incidence of eleven Chlamydia species in deep respiratory secretions.
Secondary outcome
Secondary: incidence of eleven Chlamydia species faecal samples. Tertiary:
level of agreement between between deep respiratory secretions and faecal
samples. comparison between animal contact between patients with our without
chlamydial infection. Comparison between patient characteristics of patients
with or without chlamydial infection. Comparison between clinical outcomes of
patients with or without chlamydial infection.
Background summary
The current world population is 7.8 billion as of January 2020 and is ever
increasing. Due to this growing population, together with global warming, the
risk of severe epidemics is rising. Most new epidemics are associated with an
animal origin. As such, awareness of zoonotic diseases is highly important.
Among the zoonotic respiratory infections, Chlamydiae are increasingly
identified. Wherease C. psittaci and C. pneumoniae were already known, lately
also C. gallinacea, C. avium and C. cavia have been involved in respiratory
infections occasionally. Unfortunately, since the pathogens are not routinely
tested, the incidence of these infections remains unclear.
Study objective
in this study we aim to investigate incidence of eleven Chlamydia species in
deep respiratory secretionss from patients with community acquired pneumonia.
The additional value of faecal samples will be investigated. In addition, we
aim to characterize clinical patient factors and outcomes in these Chlamydia
infections.
Study design
Prospective cohort design. Adult patients are included when they present with
community-acquired pneumonia (CAP) at the Emergency Department or Outpatient
department and are admitted to the hospital.
Study burden and risks
in addition to routine clinical data, the patients will be questioned about
animal contacts and they will be asked for collection of faecal samples.
Henri Dunantstraat 5
Heerlen 6419PC
NL
Henri Dunantstraat 5
Heerlen 6419PC
NL
Listed location countries
Age
Inclusion criteria
- Adult
- Pneumonia defined by a new pulmonary infiltrate on chest radiograph described
by the attending physician, in combination with at least two of the following
criteria: cough, sputum production, temperature > 38.0 °C or < 35.0°C,
auscultatory findings consistent with pneumonia, C-reactive protein
concentration > 15 mg/l, and white blood cell count > 10 x 109 cells/l or < 4 x
109 cells/l or > 10% of rods in leukocyte differentiation.
- Active sputum production
Exclusion criteria
None
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL73844.096.20 |