To determine the accuracy with which patients with probable or proven invasive pulmonary aspergillosis and neutropenic controls can be discriminated from each other, as measured by the values of the sensitivity, specificity and accuracy.
ID
Source
Brief title
Condition
- Hepatobiliary neoplasms malignant and unspecified
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The sensitivity, specificity and accuracy.
Secondary outcome
n.a.
Background summary
We hypothesize that invasive pulmonary aspergillosis can be diagnosed through
exhaled biomarkers. The objective of this exploratory study is to identify
these biomarkers by analyzing exhaled breath of patients with and without
invasive pulmonary aspergillosis. Putative biomarkers will be studied in a
larger follow-up study or will be used to fine-tune an eNose device.
Study objective
To determine the accuracy with which patients with probable or proven invasive
pulmonary aspergillosis and neutropenic controls can be discriminated from each
other, as measured by the values of the sensitivity, specificity and accuracy.
Study design
Single center pilot study, prospective cohort.
Study burden and risks
A sample of exhaled breath and a throat and nose swab will be taken from each
patient.
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
Patient population: patients, aged 18 or older, that will undergo treatment for
a hematological malignancy expected to result in grade 4 neutropenia for more
than 7 days, e.g. hematopoietic stem cell transplantation or
induction/consolidation treatment for acute myeloid leukaemia.
Exclusion criteria
Eerder doorgemaakte invasieve mycose.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL74649.018.20 |