The first aim of this research is to identify predictors of one-year treatment response after initial clinical diagnosis in a large sample of adolescent girls with AN. The results of this study could allow us to assess different treatment strategies…
ID
Source
Brief title
Condition
- Eating disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are brain measures (fMRI, eye tracking, attentional
processes) within and between contrasts of the patient and control group at T1
and T2.
Secondary outcome
Secondary outcome parameters are neurocognitive measures.
Background summary
Anorexia nervosa (AN) is a debilitating psychiatric disorder, of which the
etiology is thought to be heterogeneous, involving multiple (neuro)biological
and psychosocial factors. The heterogeneity is perplexing, as a subset of girls
have a relatively short-lived illness and recover quite quickly, whereas others
have a prolonged illness with multiple hospitalizations and long-term
impairment. Two potential determinants of differential treatment response are
brain functioning and attentional bias. We postulate that adolescents with AN
show altered brain function, measured by fMRI and neurocognitive tasks, and an
attentional bias, measured by the probe dot task and eye tracking, towards
disorder related words and images of body shapes at time of diagnosis.
Furthermore we think that these parameters may predict treatment response after
a year of treatment.
Study objective
The first aim of this research is to identify predictors of one-year treatment
response after initial clinical diagnosis in a large sample of adolescent girls
with AN. The results of this study could allow us to assess different treatment
strategies in an attempt to curb what appears to be a deeply rooted biological
process. Second, we will investigate the association between clinically
significant changes and neurobiological, neurocognitive and attentional changes
during one-year treatment.
Study design
We will use a longitudinal case-control repeated measures design. The study is
a collaboration with mental health organizations, specialized in diagnostics
and treatment of patients with AN. After signed informed consent, assessment
will take place at inclusion (T1) and after one year (T2). Between T1 and T2,
patients with AN will receive treatment as usual; this proposal has no planned
intervention for the controls.
Study burden and risks
To our knowledge and with proper screening, there are no medical risks
associated with fMRI-scanning and eye-tracking. There are no known risks in the
administration of neuropsychological tasks and filling in questionnaires.
During the fMRI-scanning procedure, the investigator will constantly assess
whether the investigation should be stopped. The study will immediately be
ceased if the participant, the parents or the investigator desires
Wytemaweg 80
Rotterdam 3015CN
NL
Wytemaweg 80
Rotterdam 3015CN
NL
Listed location countries
Age
Inclusion criteria
patient group:
- Girls,12 to 22 years old
- Diagnostic and Statistical Manual of Mental Disorders 5th edition: criteria
for anorexia nervosa are met
- Diagnosis made within the past 12 months., control group:
- Girls 12 to 22 years old
- No history of a current DSM-5 diagnosis
- Normal weight (BMI SDS > -1.3 SD and BMI SDS < +1.3 SD)
Exclusion criteria
-Significant motor or sensory disorder (for example deaf or blind adolescents,
which would likely create differences in brain development and formation)
-Substance related disorders
-Organic psychosyndrome
-Schizophrenia or other psychotic disorders
-Claustrophobia
- Poor command of the Dutch language
- IQ<70 as measured by an intelligence test in the past, while having a healthy
weight and a normal eating pattern.
- An inability to fill in questionnaires independently
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL55175.078.16 |