The main objective of this study is to gain insight in the (reverse) remodeling process of the atria in patients with atrial fibrillation. T Analyses will be conducted on the cardiac tissue and blood samples. We aim to correlate the findings from…
ID
Source
Brief title
Condition
- Cardiac arrhythmias
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Changes in biomarkers involved in the remodelling process of the atrium in AF
will be related to the outcome after treatment.
Secondary outcome
NVT
Background summary
Atrial Fibrillation (AF) is the most common type of arrhythmia seen in clinical
practice. Its prevalence is projected to grow at least two-fold by 2050, due to
aging of the population. AF is a progressive disease and progression of the
disease varies between patients. The pathophysiological process of AF is
complex because of its multifactorial character. Increasing AF burden leads to
structural and electrical remodeling of the atria, creating a substrate that is
favourable for sustaining AF propagation, through electrical or structural
remodeling. Specifically fibrosis is known to play an important role in the
progression of the disease. However despite extensive research that has already
been performed in the field of AF the exact pathophysiological process remains
incompletely understood.
Minimally invasive treatment strategies for AF, using catheter ablation
techniques or video-assisted thoracoscopic surgery , are promising, but success
rates for these procedures are relatively low. Recognizing patients that are
prone for recurrence of AF remains a challenge when determining a proper
treatment strategy. The ability to identify subgroups of patients that can
benefit from a specific treatment strategy might provide more individualized
therapeutic opportunities, improve prognostication or provide preventive
opportunities in patient with AF.
Study objective
The main objective of this study is to gain insight in the (reverse) remodeling
process of the atria in patients with atrial fibrillation. T Analyses will be
conducted on the cardiac tissue and blood samples. We aim to correlate the
findings from these analyses with clinical characteristics of patients with
atrial fibrillation and to compare these findings with findings from analyses
on atrial tissue, fat and blood from a control population. With these results
we aim to identify both non-invasive and invasive diagnostic markers to
determine the pathophysiological process of AF in individual patients
Study design
The study is a single center study.
Study burden and risks
The collection of blood poses no significant risk to the patients.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
- Patients with AF, undergoing VATS-PVI
- Age between 18 and 80 years
- Symptomatic AF, paroxysmal, persistent or longstanding persistent
- AF was documented on ECG/Holter/Pacemaker electrogram at least once in the 12
months preceding presentation
Exclusion criteria
- Left ventricular ejection fraction < 30%
- Severe heart failure (NYHA IV)
- Pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL50069.018.14 |