Optimizing ultrasound parameters to enhance quantitative skeletal muscle ultrasound as diagnostic imaging technique to evaluate fatty infiltration of the supra- and infraspinatus muscle in patients with rotator cuff tears.
ID
Source
Brief title
Condition
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Fatty infiltration of the supra- and infraspinatus in patients with rotator
cuff tear, measured on ultrasound by using Computed Assisted Grey Scale
Analysis with standard histogram function and Matlab.1 To reduce measurement
variation we use both short- and long-axis images of the supra-, and
infraspinatus guided by anatomic landmarks. Using both axis we will evaluate
grey scale intensities in two orthogonal scanning directions of each rotator
cuff muscle. This will give a representative impression of the amount of fat in
each individual muscle. Fatty infiltration on magnetic resonance imaging will
be evaluated by the proportion of fat in the muscle on three different
sagittal-oblique and coronal-oblique T1 images using modified Goutallier
grading system. The ultrasound, magnetic resonance imaging and consultation
will be conducted within three weeks.
Secondary outcome
- Muscle Echo Intensity (ipsilateral and contralateral rotator cuff)
- Mean grey value ipsi- and contralateral rotator cuff
- Internal architecture rotator cuff, deltoid, trapezius (ipsi- & contralateral)
- Accuracy, sensitivity, specificity, reliability of ultrasound vs. magnetic
resonance imaging
- Mean modified Goutallier score
Background summary
In rotator cuff tears (RCT) fatty infiltration grade 3-4 is generally seen as a
contra-indication for rotator cuff repair1-4. Evaluation of fatty infiltration
is performed by Magnetic Resonance Imaging (MRI) using the Goutallier-score.
However, this is a visual score and several researchers have questioned its
reliability and validity7-9;11-13. Recently several studies focused on
quantitative fat fraction measurements on MRI14. An alternative technique to
measure fatty infiltration is ultrasound1. Ultrasound has several advantages
since it is less time consuming, has lower costs and is less invasive for the
patient1. Therefore, we developed quantitative-muscle-ultrasound for measuring
fatty infiltration.
In our previous study we showed that quantitative muscle ultrasound was
directly linked to fat fraction on MRI and could be used as a more objective
and reliable alternative to assess fatty infiltration within the supraspinatus
muscle.26 Therefore, the use of quantitative ultrasound is a promising
diagnostic alternative in the assessment of fatty infiltration in rotator cuff
tears.
In this study we would like to optimize ultrasound settings. Advantages of this
improvement are that quantitative ultrasound become more accurate and have a
stronger correlation with fat fraction on MRI. Another major advantage is that
this improvement could benefits patients because ultrasound is less time
consuming and less invasive. Furthermore, this improvement might lower
healthcare cost due to the fact that ultrasound is less expensive, less time
consuming and in the future might be performed outside the hospital.
Study objective
Optimizing ultrasound parameters to enhance quantitative skeletal muscle
ultrasound as diagnostic imaging technique to evaluate fatty infiltration of
the supra- and infraspinatus muscle in patients with rotator cuff tears.
Study design
This study is a prospective cohort trial, comparing multiple quantitative
muscle ultrasound images acquired with different ultrasound parameters using
Computed Assisted Grey Scale Analysis1,3 with the current standard reference,
Magnetic Resonance Imaging (MRI) for the assessment of fatty infiltration in
patients with RCT.
Study burden and risks
There are no extra risks or burden associated with participation.
Toneellaan 2
Zoetermeer 2725 NA
NL
Toneellaan 2
Zoetermeer 2725 NA
NL
Listed location countries
Age
Inclusion criteria
Patients with a Rotator cuff tear
Exclusion criteria
No rotator cuff tear
Design
Recruitment
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| CCMO | NL69520.098.19 |