1. Evaluation of the variation of semen characteristics in the general population2. Evaluation of the variance of testosterone levels in the general population
ID
Source
Brief title
Condition
- Endocrine disorders of gonadal function
- Sexual function and fertility disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Semen characteristics, including volume, sperm concentration and fraction of
progressive motile spermatozoa) and testosterone levels.
Secondary outcome
Not applicable.
Background summary
Age-specific reference values for semen characteristics and testosterone levels
in the general population are lacking, but can positively strengthen research
concerning impaired spermatogenesis en testosterone deficiency in high risk
populations. A general population control group is essential for the DCOG-LATER
male gonadotoxicity study, which will provide an accurate estimate of overall
and treatment specific relative and absolute risks of azoospermia and
testosterone deficiency in male survivors of childhood cancer.
Study objective
1. Evaluation of the variation of semen characteristics in the general
population
2. Evaluation of the variance of testosterone levels in the general population
Study design
This study is an single-center, cross-sectional, observational study.
Study burden and risks
Participants will be asked to complete one questionnaire at home, which will
focus on reproductive history, pubertal development and questions concerning
testosterone level. This questionnaire will take about 20 minutes to complete.
In addition, participants will be asked to visit the University Medical Center
Groningen (UMCG) once in order to provide one blood sample which will be
collected in the morning, before 10 AM, and to provide a semen sample. The
duration of the visit to the UMCG is estimated circa 90 minutes. There are no
adverse events expected during the collection of semen and blood samples. The
provided reference dataset of semen characteristics and testosterone levels in
the general population will serve as a control group in research assessing the
effects of various factors on male gonadal function, e.g. severe systemic
illness (renal failure, hepatic cirrhosis, cancer), morbid obesity, exposure to
toxins (alcohol, marijuana, smoking), and nutritional deficiencies.
Geert Grooteplein Zuid 8
Nijmegen 6525 GA
NL
Geert Grooteplein Zuid 8
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
Male participants from the Lifelines cohort who are aged between 18 and 55
years.
Exclusion criteria
Participant has been treated for cancer in the past
Participant is vasectomised
Participant had fever in the last three months
Participant works night shifts
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL64583.042.18 |