To determine measurement reproducibility and analytical congruency in sequential measurements of the sublingual microcirculatory profiles at the bedside.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
microcirculatie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter is to determine the within-patient reproducibility
of the sequential measurement of the microcirculatory region of interest in
critically ill children.
Secondary outcome
The second aim is to design a more practical way to analyze and interpret the
microcirculatory bedside derived datasets. Sublingual microcirculatory
measurements will be evaluated with a CytoCam, an optical spectroscopic
sensor-based digital video imaging instrument (Braedius Medical BV, The
Netherlands). Sublingual microcirculation profile consists of blood vessel
diameter (BVd), proportion of perfused vessels (PVV), perfused vessel density
(PVD), microcirculatory flow index (MFI) and total vascular density (TVD).
Background summary
Measurement of the sublingual microcirculation is an important additional
parameter in critically ill patients. To view the microcirculation incident
dark-field imaging is used and video-clips are recorded to evaluate blood flow.
However, to date there still exist discrepancies in time consuming analyses of
microcirculatory measurements obtained from two different time points and this
makes extrapolation of data for bedside diagnostics challenging.
Study objective
To determine measurement reproducibility and analytical congruency in
sequential measurements of the sublingual microcirculatory profiles at the
bedside.
Study design
Single center, prospective, observational pilot study.
Study burden and risks
This study uses a non-invasive technique to determine the sublingual
microcircualtion. The procedure will be performed in children that are sedated
because of mechanically ventilation. Because of these two aspects there is no
burden and risk for the patient. It is an observational studie and therefore
the patient has no benefit participating in the study.
Meibergdreef 9
Amsterdam 1011 AZ
NL
Meibergdreef 9
Amsterdam 1011 AZ
NL
Listed location countries
Age
Inclusion criteria
-mechanically ventilation for at least 24 hours
-sedation
-0-18 years
Exclusion criteria
-no written informed consent from both parents
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL69233.018.19 |