In this study we try to elucidate the possible contribution of inflammation of the joint mucosa to the development of knee osteoarthritis. If we understand more about the inflammatory processes in the synovium that are important in further…
ID
Source
Brief title
Condition
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Marker expressions in the blood and mucosal tissue of patients with recurrent
patellar (sub)luxation, indicating the inflammatory status of the patient.
This will be linked to clinical data on pain and function at baseline.
Secondary outcome
Correlation between RNA sequencing data on processes in the synovium and
progression data on pain and function.
Background summary
People who suffer from a kneecap that repeatedly (sub)luxates undergo surgical
treatment for this. It is often seen that the mucous membrane tissue in the
joint shows inflammation during the operation. Some of the patients also
develop osteoarthritis in the knee. The contribution of the inflammation of the
joint mucosa to this is still unknown.
Study objective
In this study we try to elucidate the possible contribution of inflammation of
the joint mucosa to the development of knee osteoarthritis. If we understand
more about the inflammatory processes in the synovium that are important in
further development of osteoarthritis, it will eventually be possible to design
a therapeutic approach in order to prevent the development of further damage.
One of the options, for example, is the use of stem cells that may be able to
influence processes in the mucous membrane.
Study design
Explorative biological analyses in a cross-sectional patient cohort.
Study burden and risks
A study visit with physical examination and blood sampling, and synovial fluid
sampling and joint biopsies during surgery. Risk score classification: low.
Geert Grootplein zuid 10
Nijmegen 6525 GA
NL
Geert Grootplein zuid 10
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
16 years or older
Patients with a history of recurrent patellar dislocations of the index knee.
Exclusion criteria
Patients with an active inflammatory or infectious co-morbid disease (including
rheumatic diseases).
Patients who had previous surgery on the index knee
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL83924.091.23 |