Investigating the function of monocytes and their precursor cells originating from circulation, bone marrow, and spleen in the context of ovarian cancer.
ID
Source
Brief title
Condition
- Miscellaneous and site unspecified neoplasms benign
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Characterizing the immune status of ovarian carcinoma patients compared to
cancer-free controls, with a focus on hematopoietic organs and the immune cells
originating from them. This will be accomplished by assessing the
transcriptional, epigenetic, and functional programming of circulating
monocytes and myeloid precursor cells in OC.
Secondary outcome
none
Background summary
Ovarian cancer (ovarian carcinoma) is one of the most deadly forms of cancer,
as the disease is often diagnosed only in a late stage. Standard therapy
consists of (interval) debulking surgery followed by chemotherapy. Despite this
aggressive treatment, the five-year survival rate is less than 30%. To improve
outcomes for patients, it is important to understand the pathophysiology of
ovarian carcinoma from a systemic perspective, with a particular focus on the
role of immune cells, as there is an immunosuppressive status in ovarian
carcinoma. Very little is known about the function of monocytes and their
precursor cells originating from the blood, bone marrow, and spleen in ovarian
carcinoma patients. A better understanding of these systemic processes will
contribute to the development of new therapies for ovarian carcinoma patients.
Study objective
Investigating the function of monocytes and their precursor cells originating
from circulation, bone marrow, and spleen in the context of ovarian cancer.
Study design
Researcher-initiated, single-center exploratory cross-sectional study at the
Catharina Hospital in Eindhoven.
Study burden and risks
The risks are limited and include the possibility of hematoma formation with
both venipuncture and bone marrow aspiration, and in women undergoing
debulking, a puncture of the spleen.
Michelangelolaan 2
Eindhoven 5623EJ
NL
Michelangelolaan 2
Eindhoven 5623EJ
NL
Listed location countries
Age
Inclusion criteria
-Subjects should be at least 18 years old and mentally competent
-Newly diagnosed patients with ovarian carcinoma (OC) who go for primary
debulking surgery or patients with OC are scheduled for interval debulking
- Controls: women who undergo surgery for benign gynaecological conditions
under general anaesthesia
Exclusion criteria
-Mentally incompetent
-Pregnant or breastfeeding
-Known inflammatory or infectious diseases or an immunosuppressive status
-Using medication interfering with the immune system
-Severe comorbidities: other active malignancy (except for basal cell carcinoma
and other in situ carcinomas)
-Serious psychiatric pathology
-A self-reported alcohol consumption of >21 units per week
-Bleedings disorder
-History of splenectomy
-Not mastering the Dutch language
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL86399.015.24 |