The aim of this study is to characterize the immune system and its changes over time. We aim to identify the factors that influence the kinetics of immune system aging, to describe potential aging endotypes in different individuals, and correlate…
ID
Source
Brief title
Condition
- Other condition
- Cardiac disorders, signs and symptoms NEC
- Immune disorders NEC
Synonym
Health condition
systemische veroudering
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
We refer to the protocol, sections 2 and 5
Secondary outcome
N/A
Background summary
Despite an increase in lifespan over the last decades, our healthspan lags
behind. In our aging population, t is pressing that we prevent age-related
morbidities and associated burden on the health care system. Instead of
investigating aging in already aged populations, the currently proposed study
aims to elucidate the process of immune aging in relation to biological aging,
demographic and lifestyle factors and to identify early biomarkers and pathways
associated with fast versus slow immune aging and aging endotypes.
Study objective
The aim of this study is to characterize the immune system and its changes over
time. We aim to identify the factors that influence the kinetics of immune
system aging, to describe potential aging endotypes in different individuals,
and correlate them to functional immunological and clinical outcomes
Study design
A single-center, observational prospective cohort study in the Netherlands.
Participants from priorly established cohorts will be invited to join the
EVIA-study. We will obtain demographic and basic clinical data and biological
samples (blood and stool) at baseline and after three years, with a short,
yearly online questionnaire in between.
Study burden and risks
This trial does not include groups that are considered vulnerable, or any
intervention. Although venous puncture is an invasive measurement and has some
risks (e.g. formation of a hematoma), these are considered negligible. The
amount of blood drawn (85ml per timepoint) is not expected to have any negative
consequences. The questionnaires employed are general and do not contain
questions about particularly sensitive subjects.
Geert Grooteplein Zuid 10
Nijmegen 6525 GA
NL
Geert Grooteplein Zuid 10
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
- Aged between 18 and 60 years;
- Able to communicate orally in Dutch or English;
- Able to give informed consent.
Exclusion criteria
- Any systemic disease or condition, or the use of systemic medication, with
the exception of the following:
o Cardiovascular disease and related medication
o Metabolic syndrome, including diabetes, hypertension, and hyperuricemia
- Pregnancy at inclusion (will be recorded during study);
- Acute illness or fever <1 month before inclusion;
- Received vaccines or antibiotics 3 months before inclusion;
- Participation in an intervention trial;
- Legally incapacitated or unwilling to provide informed consent.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL86288.091.24 |