In adults patients with ischemic stroke and transient ischemic attack, how often does (subclinical) AF occur?
ID
Source
Brief title
Condition
- Cardiac arrhythmias
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
occurrence of (subclinical) AF.
Secondary outcome
Risk factors for AF
Cognitive deficits
Depression, fatigue, return to work and quality of life
Background summary
Atrial fibrillation (AF) is the most frequent cause of cardioembolic stroke,
with increasing prevalence and incidence, especially in older patients. Up to
25% of all ischaemic strokes can be attributed to AF, either previously known
or detected during diagnostic workup after a stroke. Identification of AF is
essential, as anticoagulant treatment, which is only given if AF is detected,
is highly effective for the prevention of ischaemic stroke recurrence. In
patients with no history of AF, it can sometimes be difficult to detect AF
given its paroxysmal and asymptomatic occurrence.
Study objective
In adults patients with ischemic stroke and transient ischemic attack, how
often does (subclinical) AF occur?
Study design
Single center prospective cohort study
Study burden and risks
All patients will be contacted by phone at 3, 6 and 12 months, and they will be
administered questionnaires related to incident (cardio)vascular disease and
cognitive impairment. In addition, blood will be collected once. During
admission, in addition to the stroke diagnostic workup, in a subset of
patients, cognitive screening, MRI and physical activity will be performed.
Afterwards, patients will visit the research center for cognitive screening,
MRI assessment and physical activity (at 3 and 12 months).
Geert Grooteplein Zuid 10 410
Nijmegen 6525 GA
NL
Geert Grooteplein Zuid 10 410
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
• Patients with the diagnosis of ischaemic stroke with neuroimaging
confirmation of cer-ebral ischemia (tissue-based definition), either with CT or
MRI
• Age 18 years or older, both male and female
• Written consent by patients or legal representative
• Diagnosis with and without atrial fibrillation
Exclusion criteria
• Unable or unwilling to participate or consent
• For the MRI-substudy: Unwillingness to undergo MRI, or contra-indication for
MRI
• Pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL86346.091.24 |