To assess the long-term clinical outcomes using Patient-reported Outcome Measures (PROMS), physical examination and radiological sequelae of acute septic arthritis in children.
ID
Source
Brief title
Condition
- Bacterial infectious disorders
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The patient-reported outcome measures (PROMs) consist of two general
questionnaires and one joint-specific outcome measure
Secondary outcome
During this visit, the range of motion of the affected and contralateral
joints, any length discrepancy and growth disturbance will be assessed. X-rays
will be made for radiological evaluation of any sequelae, including cartilage
degeneration, osteo-arthritis and avascular necrosis.
Background summary
Acute septic arthritis in children is an orthopaedic emergency. A delay in
diagnosis and inappropriate treatment can result in a devastating damage to the
joint with lifelong disability as a consequence. The clinical presentation can
be a diagnostic challenge, especially in young children. The diagnosis of acute
septic arthritis is highly suggestive when pus is aspirated from the joint, in
case of a positive culture or a positive gram stain of the joint fluid, or if
there is a white blood-cell count in the joint fluid of more than 50000/mm3.
Recent systematic reviews have identified the most effective drainage
techniques, including needle aspiration, arthroscopy and arthrotomy, depending
on the affected joint. However, the studies about the optimal drainage
procedure of the several joints were diverse and the scientific quality was
generally low. The follow-up was short and low numbers of patients were
investigated. Through our proposed research we aim to better inform the
patients and their parents about the long-term effects of septic arthritis in
children and hopefully improve treatment in the future.
Study objective
To assess the long-term clinical outcomes using Patient-reported Outcome
Measures (PROMS), physical examination and radiological sequelae of acute
septic arthritis in children.
Study design
Multi-center retrospective cohort study
Study burden and risks
No direct burden or risk (see Summary page 8 protocol).
Molengracht 21
Breda 4818CK
NL
Molengracht 21
Breda 4818CK
NL
Listed location countries
Age
Inclusion criteria
- Population: all patients aged between 0 and 17 years during the diagnose of
acute septic arthritis
- Treated over a time period from the start of electronic patient records until
2018 in one of the five regional top clinical or academic hospitals.
- The diagnosis of acute septic arthritis have to fulfill at least one of the
following criteria:
1. Pus aspirated from the joint
2. A positive culture of the joint fluid;
3. White blood cell count in the joint fluid > 50.000/mm3
Exclusion criteria
1. Intellectually disabled
2. A language barrier
3. No informed consent
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL84359.100.23 |