The primary objective of the study is to determine the incidence and aetiology of symptomatic and asymptomatic respiratory virus infections in hospital workers (HCW) and animal workers (AW). The secondary objective is to evaluate immune responses…
ID
Source
Brief title
Condition
- Viral infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study endpoint is the early detection of respiratory virus infections
that occur in HCW or AW, and the identification of the causative agent during
the observation period.
Secondary outcome
Secondary study endpoints include the assessment of local and systemic
virus-specific immune responses, risk factors, data on infection kinetics, and
genetic variation between causative viruses after a respiratory tract infection
or vaccination against respiratory viruses.
Background summary
Outbreaks with viruses occur continuously, and novel viruses or new variants of
existing viruses can surface after a zoonotic event or human-to-human
transmission. This project proposal is designed to detect early circulation of
(novel) respiratory viruses in both symptomatic and asymptomatic participants,
either by direct detection of the virus or changes in local or systemic
immunity. Additionally, SENTINEL will provide information on infectivity and
(protective) immune responses in viral outbreaks or vaccination campaigns.
Study objective
The primary objective of the study is to determine the incidence and aetiology
of symptomatic and asymptomatic respiratory virus infections in hospital
workers (HCW) and animal workers (AW). The secondary objective is to evaluate
immune responses against respiratory viruses and vaccines.
Study design
Prospective follow-up study of HCW and AW to establish a biobank in which
incidence, infection kinetics and virus-specific immune responses can be
investigated.
Study burden and risks
In this protocol, nose samples and venepunctures will be obtained from
participants at multiple timepoints over a maximum period of 5 years. The
procedures will either take place in the hospital or via home sampling. The
risk of the proposed procedures is negligible. Participants have no direct
benefit from this study other than that they will be notified when validated
PCR tests detect recent virus infections to allow them to take personal
measures to prevent spread accordingly.
Dr Molewaterplein 40
Rotterdam 3015GD
NL
Dr Molewaterplein 40
Rotterdam 3015GD
NL
Listed location countries
Age
Inclusion criteria
18 years old and above
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL86800.078.24 |