The aim is to investigate the effects of breaking up sitting with different frequencies of PA bouts on cognitive function and glucose metabolism in young sedentary adults.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Breaking up sitting with walking breaks
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome is mental flexibility assessed using the computer-based
Trial Making Test.
Secondary outcome
The secondary outcomes, as further measure of cognitive function, are
interference and memory respectively assessed by the computer-based Stroop
task, n-Back Test and attention measured by paper-based d2 attention test.
Moreover, as secondary outcomes variables characterizing the glucose metabolism
will be measured (e.g., plasma glucose, and serum insulin). Serum brain-derived
neurotrophic factor (BDNF), serum triacylglycerol (TAG), and mood are the
exploratory outcomes.
Background summary
Sedentary behavior (SB) has been associated with impaired cognitive function in
elderly, and negatively impacts glucose metabolism. Interrupting sitting with
physical activity (PA) bouts probably exerts beneficial effects on cognitive
function via an improved glucose metabolism. Nevertheless, the impacts of
breaking up prolonged sitting with various frequencies of PA bouts remain
unexplored in young sedentary adults. Moreover, we hypothesize that the pattern
of the breaks modifies the effects. Thus, randomized controlled trials (RCTs)
are highly needed to investigate the effects of interrupting sitting with
different frequencies of PA breaks on cognitive function and glucose
metabolism. We hypothesize that interrupting sitting with different frequencies
of walking breaks differentially affect cognitive function and glucose
metabolism.
Study objective
The aim is to investigate the effects of breaking up sitting with different
frequencies of PA bouts on cognitive function and glucose metabolism in young
sedentary adults.
Study design
A randomised, controlled cross-over study will be performed, consisting of four
interventions: uninterrupted prolonged sitting (SIT), short breaks (SBR),
moderate breaks (MBR), and long breaks (LBR).
Intervention
Participants will complete four conditions in a randomized, counterbalanced
order: SIT (uninterrupted prolonged sitting without any interruptions), SBR
(walk 1 minute every 10 minutes), MBR (walk 3 minutes every 30 minutes), and
LBR (walk 27 minutes during the intervention). Each condition lasts about 6
hours.
Study burden and risks
During the screening period, participants will wear the activPAL for seven
consecutive days on the right thigh to measure sedentary behaviour and physical
activity. On the four test days, cognitive function and mood will be assessed,
and blood samples will be drawn. Participants will receive a 4.5-hour SIT, LBR,
MBR, or LBR regime. Each condition including steady state and measurement time
requires about 6 hours. The walking intensity during the sitting breaks will be
set at 3.6 km/h. These regimens are safe and acceptable. Participants will have
to stay at the university and are not allowed to eat or do other activities
than prescribed in the protocol. Insertion of the cannula can cause some
discomfort and possibly a hematoma or bruise. Some participants may also report
pain during the insertion of the cannula. Other measurements are routine and
are not expected to lead to physical side effects. The data from the
participants who do not fully adhere to the study protocol will only be
included in intention to treat statistical analyses. Finally, this study will
provide insights into the potential beneficial effect of interrupting sitting
with different frequencies of walking breaks on cognitive function and glucose
metabolism in young sedentary adults. One benefit for the study population is
the opportunity to obtain guidelines for SB and PA with varying frequencies of
sitting interruptions.
UNS50 G2.220
Maastricht 6200MD
NL
UNS50 G2.220
Maastricht 6200MD
NL
Listed location countries
Age
Inclusion criteria
- Men and women aged 18-35 years;
- BMI between 18.5-24.9 kg/m2;
- SB, i.e. sitting for an average of at least 9 hours per day assessed by
activPAL;
- Physically inactive, i.e. engaging in exercise for less than 2 to 3 times per
week;
- Stable body weight (weight gain or loss < 3 kg in the past three months);
- Willingness to engage in four 6-hour laboratory visits;
- No difficult cannulation.
Exclusion criteria
- Current smoker, or smoking cessation within the last 12 months;
- Individuals diagnosed with diabetes, cardiovascular disease, or other
significant medical conditions, including epilepsy, asthma, kidney failure or
renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel
diseases, autoinflammatory diseases, and rheumatoid arthritis;
- Not sedentary, i.e. sitting for less than an average of 9 hours per day
assessed by activPAL;
- Physically active, i.e. engaging in exercise for more than 3 times a week;
- Abuse of drugs;
- Use medication to treat BP, lipid, or glucose metabolism;
- Pregnant females.
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL86254.068.24 |