The aim of this fundamental research is to optimize methods and to investigate the effects of different variables in the human body on the clot structure, contributing to the knowledge of blood clotting, cardiovascular disease, and bleeding…
ID
Source
Brief title
Condition
- Coagulopathies and bleeding diatheses (excl thrombocytopenic)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
In this fundamental research project, we study determinants of the clot
structure and how they affect the clot architecture and physical properties.
For example, the stiffness of the clot, fiber diameters, rate of fibrinolysis
and interaction of coagulation factors with cells or the endothelium will be
studied in varying conditions (e.g. modified fibrinogen, presence or absence of
flow).
Secondary outcome
Not applicable.
Background summary
The clot structure is affected by different variables in the human body, for
example modified forms of fibrinogen, glucose levels in the blood, activation
of immune cells, activation of the endothelium or the presence of flow. Changes
in the clot structure related to these variables can modify the risk of
developing cardiovascular disease and might contribute to the bleeding
phenotype of patients with a bleeding disorder.
Study objective
The aim of this fundamental research is to optimize methods and to investigate
the effects of different variables in the human body on the clot structure,
contributing to the knowledge of blood clotting, cardiovascular disease, and
bleeding disorders.
Study design
Fundamental research.
Study burden and risks
A maximum of 20 ml blood is drawn from healthy volunteers at each collection,
with a maximum of 5 times a year per donor. This is a low burden and minimal
risks are associated with participation, since only blood is drawn.
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
Voluntarily particiation,
Between 18-70 of age,
Written informed consent
Exclusion criteria
Known disease that affects coagulation;
Treatment with medication that interferes with coagulation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL78124.078.21 |