Reduce the risks associated with mechanical ventilation
ID
Source
Brief title
Condition
- Respiratory tract infections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
mortality day 60
Secondary outcome
duration of ventilation
ICU and hospital mortality
Background summary
ARDS is a major public heath problem. Treatment is challenging because there is
no treatment for the lung leak. Individualizing Ventilator settings maybe
could improve the adequacy of the ventilator.
Study objective
Reduce the risks associated with mechanical ventilation
Study design
randomized clinical trial with adaptive design assessing the efficacy of
setting the ventilator based on measurements of respiratory mechanics
(recruitability and effort) to reduce Day 60 mortality.
Intervention
Ventilator settings on individual base
Study burden and risks
no burden and risks
36 Queen St E, Toronto 36
Canada Toronto, ON M5B 1W8
CA
36 Queen St E, Toronto 36
Canada Toronto, ON M5B 1W8
CA
Listed location countries
Age
Inclusion criteria
age > 18
moderate or severe ARDS
admission Intensive Care
Exclusion criteria
received mechanical ventilation > 7 days
known or suspected elevated intracranial pressure
known pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| ClinicalTrials.gov | NCT03963622 |
| CCMO | NL84349.100.23 |