We aim to reduce total scan time and accelerate the conventional acquisitions in patients presenting with cardiovascular disease by evaluating the novel developed non BH 3D cardiovascular scan technique and the use of the adaptive-CS-network for CMR…
ID
Source
Brief title
Condition
- Cardiac disorders, signs and symptoms NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary objective is to evaluate the image performance of the novel
developed non BH 3D cardiovascular scan technique and the use of
adaptive-CS-network in patients presenting with cardiovascular disease for the
following CMR applications:
- Cardiac anatomy and cine imaging
- Cardiac perfusion imaging
- Late gadolinium enhancement (LGE)
- Mapping techniques including T1/T1rho/T2/T2*-mapping
- Cardiovascular flow imaging
Secondary outcome
Comparison with the conventional CMR acquisition and scan times.
Background summary
Cardiac magnetic resonance (CMR) has become an established, non-invasive
imaging technique for the diagnosis and risk stratification of many
cardiovascular diseases. There is a wide variety of CMR applications and
techniques to evaluate and understand myocardial and vascular function and
disease. The acquisition of current standard CMR scans, which require multiple
breath holds (BH), can easily increase up to 1 - 1.5 hours. These relatively
long scan times with the breath holds remain a challenge for patients and
hospitals, limiting the accessibility of cardiac MRI. Reducing the total scan
time and eliminating breath holds will improve patient experience and make CMR
future-proof. The new 3D cardiac MRI sequence enables free-breathing
acquisitions without the necessity of multiple preparatory planning scans with
preserved image quality. An iterative reconstruction methods is used by using
the adaptive compressed sensing (CS) network. This can significantly reduce
total scan time.
Study objective
We aim to reduce total scan time and accelerate the conventional acquisitions
in patients presenting with cardiovascular disease by evaluating the novel
developed non BH 3D cardiovascular scan technique and the use of the
adaptive-CS-network for CMR.
Study design
Patients who are referred and eligible for cardiovascular MR by their
cardiologist will be asked to participate. A standard clinical cardiovascular
MRI protocol will be performed. After informed consent additional 3D CMR
acquisitions will be added of maximal 15 minutes. No additional or other
medication or contrast agents are administered. No special aftercare is needed.
After the scan the patient can leave the hospital and will receive further
clinical care from their own physicians following standard clinical procedure.
Imaging processing and results of the 3D CMR imaging data will be compared with
the standard scans used in regular clinical setting to assess and compare image
performance and accuracy and total scan times.
Study burden and risks
We aimed to minimize burden for participants as much as possible. The
participants will not receive any additional contrast fluids or other invasive
measurements such as blood tests other than is necessary in the clinical
setting to be able to address the question of the referring clinician. The risk
associated with an additional scan time of 15-minutes is considered to be
minimal. The remaining risks for the participants are the usual risks for a MRI
scan and are minimized by the exclusion criteria and standardized MR safety
protocols from the Radiology department. We consider the remaining risks
neglectable for the participants of this study.
Albinusdreef 2
Leiden 2333ZA
NL
Albinusdreef 2
Leiden 2333ZA
NL
Listed location countries
Age
Inclusion criteria
- Eligable for cardiac MR assessment
- Age >= 18 years
- Written informed consent
Exclusion criteria
- Exclusion criteria for MRI (claustrophobia, pacemaker, metal implants, etc.)
- A psychiatric, addictive or any other disorder that compromises the subjects
ability to understand the study content and to give written informed consent
Design
Recruitment
Medical products/devices used
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL85313.058.24 |