The main aim of the study is to compare the optimal protein intake of a protein with a high quality (milk) to the optimal protein intake of a protein with a low quality (wheat) in healthy older adults using the indicator amino acid oxidation (IAAO)…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Eiwitbehoefte
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary endpoint is to identify differences in optimal protein intake
deriving from a protein with a high quality (milk) and a protein with a low
quality (wheat).
Secondary outcome
De secondary outcomes are the determination of the estimated average
requirement (EAR) for both milk and wheat protein, and the recommended daily
allowance (RDA) for both milk and wheat protein.
Background summary
Dietary protein intake is essential for tissue renewal and growth. Current
recommendations for protein intake are based on studies using egg protein as
reference protein. Egg protein is an animal-based protein with a high quality.
Protein quality is determined by the composition of (essential) amino acids and
digestibility. Therefore, different proteins have a different quality. Due to
the environmental crisis, an increasing number of people consumes more
plant-based proteins. These plant-based proteins often have a lower protein
quality compared to animal-based proteins. Therefore, the aim of this study is
to investigate whether optimal protein intake depend on protein quality. The
optimal protein intake of an animal-based protein with a high quality (milk)
will be compared to the optimal protein intake of a plant-based protein with a
low quality (wheat).
Study objective
The main aim of the study is to compare the optimal protein intake of a protein
with a high quality (milk) to the optimal protein intake of a protein with a
low quality (wheat) in healthy older adults using the indicator amino acid
oxidation (IAAO) technique
Study design
Randomized, double-blinded, parallel study design.
Intervention
Subjects will be divided into two groups receiving either milk or wheat
protein. The subjects receiving milk protein will consume a test diet
containing 0,1, 0,3, 0,6, 0,9, 1,2, 1,5, and 1,8 gram protein/kg/d during 7
separate acute metabolic trials. For wheat protein, test diets contain 0.1,
0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 gram protein/kg/d during 7 separate acute
metabolic trials
Study burden and risks
The burden and risks of participation are small. The risk of the catheters is
minimal and includes only a small hematoma. Sampling breath does not bring
additional risks. Participants will be contacted within 1 week after completing
the experimental trials to ask whether they experienced any discomfort from the
interventional compounds. Participants will come to the university eight times:
1 screening (~2h) and 7 experimental days (~8h each). Subjects will be
instructed in the two days prior to test days not to perform any type of
intense physical activity and to consume a maintenance diet that will be
provided by the researchers. Participants will be asked to record their daily
activities in the two days prior to the first experimental test day.There is no
direct benefit to the participant, only their contribution to the scientific
knowledge about optimal protein intake and knowledge about their individual
optimal protein intake.
Universiteitssingel 50
Maastricht 6229 ER
NL
Universiteitssingel 50
Maastricht 6229 ER
NL
Listed location countries
Age
Inclusion criteria
Aged between 65-85 years
BMI between 18.5-30 kg/m^2
No physical limitations
Maximal one intensive exercise training per week
Exclusion criteria
Smoking
Diagnosed musculoskeletal disorders
Use of any medications known to affect protein metabolism
Chronic use of gastric acid-suppressing medication or anti-coagulatns
Unstable weight over the last 3 months
Diagnosed GI tract disorders or diseases
Blood donation in the past 2 months
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| CCMO | NL87664.068.24 |