Objective 1: The LifeMeds cohort aims to longitudinally identify characteristics of individuals with multimorbidity (at least two of the following chronic diseases: CVD, CRDs,T2DM and/or cancer), including lifestyle behavior and its determinants. 1a…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
multimorbiditeit (type 2 diabetes, hart- en vaatziekten, chronische luchtwegaandoeningen en/of kanker)
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Lifestyle variables include physical activity, dietary intake, alcohol
consumption, sleep, stress, medication adherence, smoking and weight control.
Determinants include sociodemographic, medical, social and psychological
factors.
Endpoints:
- Mortality: all-cause and cardiovascular
- Hospitalizations during the first year post- percutaneous coronary
intervention, includ-ing elective and acute hospitalizations.
- Major Adverse Cardiac Events (myocardial infarction, coronary artery bypass
graft, heart transplantation, revascularization)
Secondary outcome
Not applicable
Background summary
Although there is a growing number of individuals with multimorbidity, previous
studies have predominantly focused on single diseases. It is known that
unhealthy lifestyle behaviors are more prevalent among individuals with
multimorbidity compared to those with a single morbidity. Consequently, the
encouragement of healthy lifestyles is essential, yet challenging given the
lack of knowledge regarding determinants of lifestyle behaviors and future
morbidity and mortality in this population. Therefore, the LifeMeds cohort aims
to longitudinally identify sociodemographic, medical, social, and psychological
determinants of lifestyle, morbidity and mortality in individuals with
multimorbidity. The findings will support the development of
disease-overarching approaches, tailored to the needs and characteristics of
the individual with multimorbidity, rather than focusing on disease-specific
approaches.
Study objective
Objective 1: The LifeMeds cohort aims to longitudinally identify
characteristics of individuals with multimorbidity (at least two of the
following chronic diseases: CVD, CRDs,T2DM and/or cancer), including lifestyle
behavior and its determinants.
1a. To longitudinally characterize lifestyle trajectories of individuals with
multimorbidity and to identify potential similarities and differences in
lifestyle
trajectories between individuals with different combinations of multimorbidity.
1b. To identify determinants of lifestyle behaviors in individuals with
multimorbidity and monitor changes over time.
1c. To link different lifestyle-trajectories to future morbidity and mortality
risk.
Objective 2:
To investigate the impact of multimorbidity on health outcomes, including
quality of life, mortality and other significant health events, and to identify
the sociodemographic, medical, social and psychological determinants associated
with these outcomes.
2a. To assess quality of life, morbidity and mortality risk among individuals
with different combinations of multimorbidity.
2b. To identify the clinical, sociodemographic, medical, social and
psychological determinants associated with morbidity and mortality incidence in
individuals with different combinations of multimorbidity.
Study design
The LifeMeds cohort is an observational, prospective cohort study, employing 10
yearly repeated measures to investigate the progression and development of
multimorbidity, and lifestyle behaviors and its determinants in individuals
with multimorbidity. Incident patients with multimorbidity (individuals newly
diagnosed with a second condition making them affected by multimorbidity) as
well as prevalent patients with multimorbidity (individuals who are already
living with multimorbidity) will be eligible for participation. The aim is to
recruit a large, heterogeneous sample, with various combinations of diseases to
ensure diverse representation
Study burden and risks
We expect no risk for patients participating in this study, as involvement
requires completing 1 questionnaire each year for a duration of 10 years.
Participation in this study is entirely voluntary, and participants have the
autonomy to decline or not answer items in the questionnaires.
It should be noted that participation in the study will necessitate a certain
time commitment from the participants, an estimated 10 hours required over a 10
year timespan. Additionally, some of the questions may be perceived as
sensitive, including those pertaining to personal life events, and income. This
may be confronting to some participants.
Warandelaan 2
Tilburg 5037 AB
NL
Warandelaan 2
Tilburg 5037 AB
NL
Listed location countries
Age
Inclusion criteria
- The cohort will include participants who have been diagnosed with at least
two of the following chronic diseases: T2DM, CVD, CRD, cancer. The study will
specifically include most common subtypes of diseases with etiologies strongly
linked to lifestyle-related risk factors:
1. Cancer: breast, colorectal, prostate, lung/ brochus.
2. T2DM
3. CVD: coronary artery heart disease, heart failure, peripheral artery
disease, hypertension.
4. CRD: chronic obstructive pulmonary disease, asthma.
- Aged 18 years or older
Exclusion criteria
- Refusal to informed consent
- Have significant cognitive impairment (e.g. major neurocognitive disorder)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL88127.028.24 |