We want to identify which patients will develop arthritis with the long-term and ambitious aim of trying to prevent the development of arthritis before it occurs. As many (most) participants will not develop arthritis, we are also studying the…
ID
Source
Brief title
Condition
- Joint disorders
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To identify demographic, clinical and biological predictors for the development
of PsA: Development of PsA confirmed by upload of clinic letter confirming
diagnosis.
Secondary outcome
To test the performance of the PEST screening questionnaire in identifying PsA:
Development of PsA confirmed by upload of clinic letter confirming diagnosis.
To establish the burden of psoriasis across Europe: Patient reported outcomes
including PsA impact of disease (PsAID), Multi-dimensional health assessment
questionnaire (MD-HAQ), Patient health questionnaire (PHQ-9), FACIT-fatigue.
To establish the burden of psoriasis treatment across Europe: Treatment
satisfaction questionnaire for medication (TSQM).
Background summary
HIPPOCRATES is an Innovative Medicines Initiative (IMI) funded EU Consortium
established to address key unmet clinical needs in psoriatic disease. As part
of the project, the HIPPOCRATES Prospective Observational Study (HPOS) is a
study of patients with psoriasis which will run across Europe. The study will
be led by a research team at University of Oxford and supported by a team at
University College Dublin. We are aiming to identify people with psoriasis who
are at risk of developing psoriatic arthritis. Up to one-third of patients with
psoriasis will develop a related arthritis causing inflammation in the joints
and tendons.
Study objective
We want to identify which patients will develop arthritis with the long-term
and ambitious aim of trying to prevent the development of arthritis before it
occurs. As many (most) participants will not develop arthritis, we are also
studying the impact of psoriasis on the participants to learn more about how
psoriasis affects people*s daily lives across Europe.
Study design
We are recruiting/approaching adults with psoriasis and asking study
participants to complete questionnaires every 6 months via a dedicated study
website. The questionnaires will include a *screening questionnaire* to try to
identify arthritis. If participants are identified by the *screening
questionnaire* as having possible arthritis, they will be advised to seek local
medical help. We will follow up with them to see if they are diagnosed with
psoriatic arthritis.
Alongside the questionnaire information from participants, we will ask some
participants to provide a blood fingerprick sample using an easy to use at home
sampling kit. The blood sample will be posted to a central location (University
College Dublin) where it will be stored and then studied in the laboratory to
look for markers that may predict the onset of arthritis.
Study burden and risks
Low risk as this is a non-interventional remote study.
Windmill Road n.v.t.
Oxford OX3 7LD
GB
Windmill Road n.v.t.
Oxford OX3 7LD
GB
Listed location countries
Age
Inclusion criteria
Adults with psoriasis
Exclusion criteria
Pre-existing diagnosis of psoriatic arthritis
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL86378.018.24 |