The overall aim of the Ageinglines cohort study is to better understand the biological ageing process and its association with the onset (pre)frailty and well-being in later life and to identify targets for delaying the biological ageing process…
ID
Source
Brief title
Condition
- Hearing disorders
- Glaucoma and ocular hypertension
- Dementia and amnestic conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is frailty according to the deficit accumulation model
of Rockwood. This model postulates that the proportion of ageing-related health
deficits, i.e. the Frailty Index (FI), reflects biological age over
chronological age. For the construction of the Frailty Index (FI), we will
follow the guidelines of Searle and colleagues by including health deficits on
the following frailty dimensions: physical frailty, cognitive frailty,
emotional frailty, sensory frailty, metabolic frailty and social frailty. Each
of these health deficits can be characterize as biologically meaningful in
representing multiple organ systems and accumulate with age. Each deficit was
coded as 0 (absence) or 1 (presence) or when clinically relevant, as any number
between 0 and 1. The frailty score will be calculated for each individual by
dividing the sum of health deficits scores by the number of health deficits
measured. This will result in a score between 0 (no deficits present) and 1
(all deficits present). The higher the deficit count, the frailer and more
vulnerable individuals are to adverse outcomes. For clinical interpretation,
people can be classified as robust (FI <0.08), pre-frail (0.08 <= FI < 0.25),
and frail (FI >=0.25).
Secondary outcome
The following secondary parameters will be included:
1. Physical functioning
a. Short Physical Performance Battery (SPPB) consisting of balance, gait speed
(4 meter), and 5 chair stand up test
b. Physical activity and gait speed measured with a accelerometer (MOX1
Activity Logger; Maastricht Instruments BV, Netherlands, CE certified)
c. Grip strength (maximum grip strength measured at both arms 3 times with 20
sec rest intervals using Jamar handdynamometer)
d. Sarcopenia (SARC-F questionnaire)
e. Instrumental Activities of Daily Living (iADL questionnaire of Lawton)
f. Activities of Daily Living (ADL Katz questionnaire)
2. Mental functioning
a. Depressive symptoms (CES-D questionnaire)
b. Loneliness (De Jong-Gierveld questionnaire)
3. Cognitive functioning
a. Stroop task
b. Montreal Cognitive Assessment (MOCA)
c. 15-Word Verbal Learning Test
4. Well-being
a. Well-being (Warwick-Edinburgh Mental Wellbeing Scale)
Background summary
The western society faces a so-called *double ageing* process due to an
increasing life expectancy and decreasing birth rate. In the Netherlands, the
number of people aged 65 years and older will increase from 3.4 million in 2020
to 5.0 million in 2060, reflecting 19% and 25% of the total population
(Statistics Netherlands). The disease-free life expectancy, however, has not
increased as much as the overall life expectancy due to an ever-improving
health care system and chronic disease management.
Thus, an average of 16-20% of late life is spent with chronic diseases (8-10)
posing a high burden on many older people. Most older people thus experience a
gradually diminishing functional status due to multimorbidity (16%) or physical
frailty (47%) in their latest stages of life. Due to the gradual and slow
progression of frailty, frail seniors often face a lower quality of life for
longer periods of time compared to patients with terminal illnesses. Frailty is
an independent risk factor for adverse health events, such as falls,
disability, hospitalization, admission to long-term care facilities, and
mortality. The origin of frailty is multifactorial and characterized by
functional decline in multiple physiological systems leading to poor resolution
of homeostasis after a stressor, irrespective whether this is a physical
stressor (e.g. hip fracture, pneumonia) or social stressor (e.g. loss of a
partner). Therefore, it is important to understand the pathways to (pre)frailty
in order to develop effective interventions to delay the ageing process and
prevent frailty resulting in a higher quality of life.
Study objective
The overall aim of the Ageinglines cohort study is to better understand the
biological ageing process and its association with the onset (pre)frailty and
well-being in later life and to identify targets for delaying the biological
ageing process that leads to frailty.
Primary Objectives
1. To investigate the predictive accuracy of a comprehensive set of biomarkers
of biological ageing on (pre)frailty among older community dwelling adults.
Secondary Objective(s):
1. To explore the moderating and mediating factors in the association between
various biomarkers of biological ageing and the development of (pre)frailty
among older community dwelling adults.
2. To investigate the determinants (of trajectories) of physical, mental and
cognitive functioning and its impact on well-being among older community
dwelling adults.
Study design
To investigate the association between a comprehensive set of biological
biomarkers of ageing and frailty among older community dwelling persons (65 to
80 years), we will perform a longitudinal cohort study aiming to include 4500
participants. Subsequently, every 5 years participants will be invited for
comprehensive examination at the study site.
Study burden and risks
All participants are invited to visit the study site at baseline and
subsequently every 5 years for comprehensive measurement including
neuropsychological testing, clinical measures (i.e. grip strength, gait speed,
eye tests, hearing tests), blood sampling for determining blood-based
biomarkers (total duration ~3,5 hours). Participants are asked to fill in
online questionnaires (3x 40 minuten) and report their movement activities in a
sleep and movement diary for 7 days (24 hours). In addition, participants will
be asked to wear an accelerometer for 7 days, 24 hours. This accelerometer is
lightweight and will be attached to the thigh with special skin-sensitive tape.
There is no need for charging or removing the device. Participants can perform
all their usual activities. Although, special skin-sensitive tape is used, it
is possible that participants experience skin irritation. After 7 days, the
participant can remove the accelerometer from its thigh and subsequently send
it, together with the sleep- and movement diary, back to the research center
using a reply envelope.
All measurements are non-invasive, except for the drawing blood sample, which
might cause mild pain and sometimes a bruise. Participants could experience
psychological stress for the neuropsychological test battery and possibly when
abnormal test results are found.
In case of abnormal results, the participant is requested to contact general
practitioner to verify the test results. Participation in the study might be
beneficial as participants receive feedback about their health status which
could encourage them to adopt a healthier lifestyle.
In summary, we consider the risks of the current study negligible, and the
burden for the participants minimal. All participants receive voucher of 25
euros for each visit at the research center for the allowance for travel
expenses.
Hanzeplein 1
Groningen 9700 RB
NL
Hanzeplein 1
Groningen 9700 RB
NL
Listed location countries
Age
Inclusion criteria
- Age between 65 and 80 years during the comprehensive examination at the
research site
- Written informed consent
- Access to internet at home to fill in online questionnaires
Exclusion criteria
- No consent of the participant to inform General Practitioner in case of
abnormal results are found during the study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL85552.099.24 |