The purpose of this study is: 1. To develop a method to quantify muscular fat content in brachial plexus injury patients; 2. To investigate whether muscular fat content is more in the affected arm compared to the contra lateral arm in BPI patients…
ID
Bron
Verkorte titel
Aandoening
Brachial plexus injury
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Percentage of muscle fattening of the m. biceps brachii.
Achtergrond van het onderzoek
A brachial plexus injury is the most severe nerve injury of the extremities. In spite of natural recovery, the majority of these patients have residual muscle weakness and need nerve and/or secondary surgery to improve the utility of their arm. Long-term denervation results in muscle atrophy, fatty degeneration and interstitial fibrosis of the muscle. Quantitative tools which assess muscular fat content could improve insight in the extent of muscle degeneration and could facilitate a better treatment strategy.
Doel van het onderzoek
The purpose of this study is:
1. To develop a method to quantify muscular fat content in brachial plexus injury patients;
2. To investigate whether muscular fat content is more in the affected arm compared to the contra lateral arm in BPI patients;
3. To evaluate differences in muscular fat content between patient groups with insufficient recovery and with sufficient recovery of muscle function.
Onderzoeksopzet
One timepoint at which MRI, physical examination and questionnaires will be performed.
Onderzoeksproduct en/of interventie
3 Tesla MRI of both upper arms.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Brachial plexus injury patients with insufficient recovery of the musculus biceps brachii (MRC 0-3) will be included in group 1 and with a sufficient recovery (MRC 4) will be included in group 2;
2. Minimum 2 years after trauma or nerve surgery;
3. More then 18 years old.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Bilateral brachial plexus injury;
2. Not 3 tesla MRI eligible due to any reason;
3. Not eligible to give informed consent.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2416 |
| NTR-old | NTR2524 |
| Ander register | MEC LUMC / ZonMW : P10.063 / 95100105 ; |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |