Chronic Obstructive Pulmonary Disease is a disease of the lungs for which adequate treatment lacks. We hypothesize that there is a role for autoimmunity in this disease.
ID
Bron
Aandoening
Chronic Obstructive Pulmonary Disease, COPD, Autoimmunity, lung, smoking, cytotoxicity, antibodies
Chronische Obstructieve Bronchitis en Longemfyseem, autoimmuniteit, long, roken, cytotoxiciteit, antilichamen
Ondersteuning
Hanzeplein 1
Postbus 30.001
9700 RB Groningen
The Netherlands
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. The degree of autoantibody-mediated cytotoxicity of sera of COPD patients when compared to non-COPD patients, expressed as a fraction of cells that have died during incubation;
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2. The cell types (primary bronchial epithelial cells, primary airway smooth muscle cells, primary lung fibroblasts) and cell lines (an alveolar epithelial cell line and a lung fibroblast cell line) that are primarily affected by autoantibodies as found in serum of COPD patients and healthy controls;<br>
3. The contribution of complement, different effector cells, and antibody-free serum to the level (as outlined in the previous paragraphs) and specificity of cytotoxicity (which cells and cell lines are affected). The impact of different effector cells and antibody-free serum.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
Chronic Obstructive Pulmonary Disease is a disease of the lungs for which adequate treatment lacks. We hypothesize that there is a role for autoimmunity in this disease.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
N/A
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Inclusion criteria for COPD patients:
1. Clinical diagnose of COPD;
2. No allergies;
3. Post-bronchodilator FEV1 < 80% predicted, and postbronchodilator FEV1/FVC < 70% (in accordance with the GOLD stages mentioned above);
4. Age > 40;
5. Current or ex-smokers > 10 pack years;
6. Ex-smokers have to have quitted smoking for at least one year;
7. No other major current health problems;
8. Written informed consent.
Healthy controls:
1. No signs of pulmonary disease;
2. No allergies;
3. No other major current health problems;
4. FEV1 > 90 % predicted and FEV1/FVC > 70%;
5. Age > 40;
6. Never smokers, i.e. no cigarettes last year, and < 5 pack years, or current smokers > 10 pack years; or ex- smokers for > 1 year and > 10 pack years;
7. Written informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Addiction to alcohol or drugs;
2. COPD exacerbation in the 6 weeks preceding the study;
3. Immunosuppressive therapy.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2135 |
| NTR-old | NTR2259 |
| Ander register | Dutch Asthma Foundation : 3.2.08.021 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |