Low frequency stimulation causes vasodilation in the affected extremity of patients with CRPS
ID
Bron
Verkorte titel
Aandoening
Complex Regional Pain Syndrome
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Difference in skin temperature between the affected and contralateral extremity for each used frequency
Achtergrond van het onderzoek
Complex regional pain syndrome (CRPS) is a complication after trauma or surgery. CRPS is characterized by a continuing regional pain in a distal extremity, often combined by vasomotor, sudomotor and motor/throphic disturbances. In the chronic phase of CRPS the affected extremity can change into a cold extremity induced by vasomotor disturbances that cause a decrease in blood flow. Spinal cord stimulation (SCS) is effective on pain in CRPS. Besides SCS also turns out to induce peripheral vasodilatation. However SCS has also some limitations that were not found in DRG stimulation. Clinical observations, however, show a positive effect on vasomotor dysfunction of Dorsal Root Ganglion (DRG) stimulation in CRPS, at least in a part of the patients. This effect seems to be frequency dependent.
The objective of this study is to investigate which frequencies of DRG stimulation have an influence on the peripheral blood flow of the affected extremity in patients with CRPS and vasomotor disturbances and should thereby be further investigated.
Doel van het onderzoek
Low frequency stimulation causes vasodilation in the affected extremity of patients with CRPS
Onderzoeksopzet
Single measurement
Onderzoeksproduct en/of interventie
Different frequencies of stimulation with a DRG stimulator. The patients already have had a DRG stimulator surgically implanted as standard care for treatment of CRPS. The frequencies used as intervention in this experiment are in the range of standard treatment.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Patients diagnosed with CRPS according to the new IASP criteria
• Patients must have vasomotor disturbance; the skin temperature of the affected extremity is at least 1°C colder than skin temperature of the contralateral extremity. This will be measured using a thermography imaging camera and determined using MatLab
• Patients must have a DRG stimulator for treatment of CRPS, that has been implanted at least three months before inclusion
• Clinically the contralateral extremity must be without signs or symptoms in a way that it can be used as a control.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Age < 18 years
• Patients diagnosed with other disease that influences the peripheral blood flow
• Patients using medication that influences peripheral blood flow
• DRG stimulator implanted within three months before inclusion
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8342 |
| CCMO | NL67598.078.18 |
| OMON | NL-OMON47944 |