N/A
ID
Bron
Verkorte titel
Aandoening
Stress
Cortisol
emotional memory
spatial memory
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
At the behavioural level, the main study parameter in the spatial memory task is accuracy (i.e. how well subjects remember the right location for a given object learned earlier) and the strategy used (i.e., automatic stimulus response association or elaborate spatial map strategy). For fear acquisition we assess how fast and accurate subjects learn the relationship between specific stimuli and threat using skin conductance responses. At the brain system level, we seek to investigate whether neural response patterns obtained by fMRI can reveal the neural mechanism by which MR activation is causing stress induced changes in spatial memory and fear learning.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
N/A
Onderzoeksopzet
1 appointment for a medical screening, 2 appointments for the actual testing (3.5h and 1h, both in the afternoon on subsequent days).
Onderzoeksproduct en/of interventie
Half of the subjects will undergo a slightly modified version of the Socially Evaluated Cold Pressure Task (SECPT; Schwabe, Haddad, & Schachinger, 2008) to induce stress. The other half will undergo a control condition meant to cause no stress. Furthermore, half the subjects of the stress- and the non stress-group will receive a single dose Spironolacton (400mg tablet) before undergoing fMRI; the other participants will receive placebo.
Algemeen / deelnemers
Donders Institute for Brain, Cognition and Behaviour
Guillén Fernández
Nijmegen
The Netherlands
Guillén.Fernández@donders.ru.nl
Wetenschappers
Donders Institute for Brain, Cognition and Behaviour
Guillén Fernández
Nijmegen
The Netherlands
Guillén.Fernández@donders.ru.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Male, healthy volunteers;
2. Age 18 - 35 years;
3. Normal or corrected-to-normal vision;
4. Normal uncorrected hearing;
5. Body mass index between 18.5 and 30;
6. Willingness and ability to give written informed consent and willingness and ability to un-derstand the nature and content, to participate and to comply with the study requirements.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Anuria;
2. Acute or history of renal insufficiency / impairment of renal excretory function (or creatinine levels > 1.1 mg/dl at screening);
3. Hyperkalemia (or potassium levels of > 5.0 mEq/L at screening);
4. History of psychiatric treatment /current psychiatric treatment;
5. History of neurological treatment /current neurological treatment;
6. History of endocrine treatment /current endocrine treatment;
7. History of autonomic failure (e.g., vasovagal reflex syncope);
8. History of psychotropic medication (e.g. antidepressants);
9. History of hepatic impairments;
10. History of cardiovascular diseases;
11. Hypotension (< 90 / 60 mmHG);
12. Bradycardia / Tachycardia (heart rate < 50 or > 100 at rest);
13. Use of any medication on a regular basis;
14. Metal objects in or around the body;
15. Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel);
16. Claustrophobia;
17. Use of recreational drugs weekly or more often;
18. Smoking of more than 5 cigarettes per day;
19. Average use of more than 3 alcoholic beverages daily and self-reported inability or un-ease to cease drinking alcohol for 24 hours prior to testing;
20. Coffeine consumption 24 hours before testing;
21. Professional sports or participation in competitions (as Spironolacton can lead to a positive doping test).
Opzet
Deelname
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In overige registers
Register | ID |
---|---|
NTR-new | NL3444 |
NTR-old | NTR3595 |
CCMO | NL37819.091.11 |
ISRCTN | ISRCTN wordt niet meer aangevraagd. |
OMON | NL-OMON35544 |